Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation
Abstract
Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors. In adult SHIP-/- mice, the NK compartment is dominated by cells that express two inhibitory receptors capable of binding either self or allogeneic MHC ligands. This promiscuous repertoire has significant functional consequences, because SHIP-/- mice fail to reject fully mismatched allogeneic marrow grafts and show enhanced survival after such transplants. Thus, SHIP plays an important role in two processes that limit the success of allogeneic marrow transplantation: graft rejection and graft-versus-host disease.
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TAM-induced Cre expression in Inpp5dfl/fl/Cx3cr1CreER/+ mice results in chronic recombination in microglia, but not in transient myeloid cells.
“in which TAM-induced Cre expression results in chronic recombination in microglia, but not in transient myeloid cells.”
From Microglial <i>INPP5D</i> limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease (2023) · cites this paper as [67]
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- Authors
- Wang, J.-W., Howson, J. M., Ghansah, T., Desponts, C., Ninos, J. M., May, S. L., Nguyen, K. H. T., Toyama-Sorimachi, N., & Kerr, W. G.
- Affiliations
- University of South Florida (US)
- Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo 113-8150, Japan.
- Corresponding author
- Wang, Jia-Wang
- Howson, Julie M.
- Ghansah, Tomar
- Kerr, William G.
- Venue
- Science
- Published
- 2002-03-15
- Volume
- 295
- Issue
- 5562
- Pages
- 2094-2097
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976255260
- Cited by
- 178
- References
- 20
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 13 · 2014: 9 · 2013: 6 · 2012: 15
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK054767)
- National Institute of Neurological Disorders and Stroke (P01NS027405)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- ships, natural killer cells, NK cell receptors, MHC class I, inhibitory receptors, allogeneic bone marrow transplantation, graft rejection, graft-versus-host disease, graft-versus-tumor effect, engraftment
- MeSH terms
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Animals, Antigens, Ly, Cell Survival, Graft Rejection, Graft Survival, Graft vs Host Disease, H-2 Antigens, Haplotypes, Killer Cells, Natural, Ligands, Membrane Glycoproteins, Mice, Inbred A, Mice, Inbred BALB C, Phosphoric Monoester Hydrolases, Phosphorylation, Proto-Oncogene Proteins, Receptors, Immunologic, Transplantation, Homologous, Histocompatibility Antigens Class I, Signal Transduction, Antigens, CD, Bone Marrow Transplantation, Lymphocyte Subsets, Protein Serine-Threonine Kinases, Lymphocyte Count, src Homology Domains, Phosphatidylinositol 3-Kinases, Lectins, C-Type, Proto-Oncogene Proteins c-akt, Mice, NK Cell Lectin-Like Receptor Subfamily D, Receptors, NK Cell Lectin-Like
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