The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level
Abstract
Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus–type 1 (HIV-1) mutations that allow escape from host immune responses may therefore be HLA allele–specific. We analyzed HIV-1 reverse transcriptase sequences from a large HLA-diverse population of HIV-1–infected individuals. Polymorphisms in HIV-1 were most evident at sites of least functional or structural constraint and frequently were associated with particular host HLA class I alleles. Absence of polymorphism was also HLA allele–specific. At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo.
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Cites
Cosmic evolution in a cyclic universe
Steinhardt, P. J., & Turok, N. (2002) · Physical Review D · doi:10.1103/physrevd.65.126003 · Cited by 813
Cited by
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
Kiepiela, P., Leslie, A. J., Honeyborne, I., Ramduth, D., Thobakgale, C., Chetty, S., Rathnavalu, P., Moore, C., Pfafferott, K. J., Hilton, L., et al. (2004) · Nature · doi:10.1038/nature03113 · Cited by 842
Self-citationAdaptation of HIV-1 to human leukocyte antigen class I
Kawashima, Y., Pfafferott, K., Frater, J., Matthews, P., Payne, R., Addo, M., Gatanaga, H., Fujiwara, M., Hachiya, A., Koizumi, H., et al. (2009) · Nature · doi:10.1038/nature07746 · Cited by 466
Self-citationReversion of CTL escape–variant immunodeficiency viruses in vivo
Friedrich, T. C., Dodds, E. J., Yant, L. J., Vojnov, L., Rudersdorf, R., Cullen, C., Evans, D. T., Desrosiers, R. C., Mothé, B. R., Sidney, J., et al. (2004) · Nature Medicine · doi:10.1038/nm998 · Cited by 369
Draenert, R., Le Gall, S., Pfafferott, K. J., Leslie, A. J., Chetty, P., Brander, C., Holmes, E. C., Chang, S.-C., Feeney, M. E., Addo, M. M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031982 · Cited by 304
Adaptation to different human populations by HIV-1 revealed by codon-based analyses
Kosakovsky Pond, S. L., Frost, S. D. W., Grossman, Z., Gravenor, M. B., Richman, D. D., & Brown, A. J. L. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020062 · Cited by 223
Metadata
- Authors
- Moore, C. B., John, M., James, I. R., Christiansen, F. T., Witt, C. S., & Mallal, S. A.
- Venue
- Science
- Published
- 2002-05-24
- Volume
- 296
- Issue
- 5572
- Pages
- 1439-1443
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063485002
- Cited by
- 740
- References
- 1
- FWCI
- 21.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level. https://app.cochat.ai/papers/10.1126/science.1069660
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- Moore, C. B., John, M., James, I. R., Christiansen, F. T., Witt, C. S., & Mallal, S. A. (2002). Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level. Science. https://doi.org/10.1126/science.1069660
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