The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells
Abstract
E2F-6 contributes to gene silencing in a manner independent of retinoblastoma protein family members. To better elucidate the molecular mechanism of repression by E2F-6, we have purified the factor from cultured cells. E2F-6 is found in a multimeric protein complex that contains Mga and Max, and thus the complex can bind not only to the E2F-binding site but also to Myc- and Brachyury-binding sites. Moreover, the complex contains chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1γ, and Polycomb group (PcG) proteins. The E2F-6 complex preferentially occupies target promoters in G 0 cells rather than in G 1 cells. These data suggest that these chromatin modifiers contribute to silencing of E2F- and Myc-responsive genes in quiescent cells.
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Cites
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
Tachibana, M., Sugimoto, K., Fukushima, T., & Shinkai, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101914200 · Cited by 784
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Metadata
- Authors
- Ogawa, H., Ishiguro, K.-I., Gaubatz, S., Livingston, D. M., & Nakatani, Y.
- Venue
- Science
- Published
- 2002-05-10
- Volume
- 296
- Issue
- 5570
- Pages
- 1132-1136
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012598468
- Cited by
- 768
- References
- 2
- FWCI
- 19.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ogawa, H., Ishiguro, K.-I., Gaubatz, S., Livingston, D. M., & Nakatani, Y. (2002). A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells. Science. https://doi.org/10.1126/science.1069861
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