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The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS
Abstract
The enediynes exemplify nature's ingenuity. We have cloned and characterized the biosynthetic locus coding for perhaps the most notorious member of the nonchromoprotein enediyne family, calicheamicin. This gene cluster contains an unusual polyketide synthase (PKS) that is demonstrated to be essential for enediyne biosynthesis. Comparison of the calicheamicin locus with the locus encoding the chromoprotein enediyne C-1027 reveals that the enediyne PKS is highly conserved among these distinct enediyne families. Contrary to previous hypotheses, this suggests that the chromoprotein and nonchromoprotein enediynes are generated by similar biosynthetic pathways.
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Citations
Cited by
Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms
Shen, B. (2003) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(03)00020-6 · Cited by 565
Combinatorial biosynthesis of reduced polyketides
Weissman, K. J., & Leadlay, P. F. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1287 · Cited by 466
Biosynthesis and function of polyacetylenes and allied natural products
Minto, R. E., & Blacklock, B. J. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.02.002 · Cited by 351
Biosynthesis of polyketide synthase extender units
Chan, Y. A., Podevels, A. M., Kevany, B. M., & Thomas, M. G. (2009) · Nat. Prod. Rep. · doi:10.1039/b801658p · Cited by 337
Feng, Y., Yang, X., Ji, H., Deng, Z., Lin, S., & Zheng, J. (2022) · Communications Biology · doi:10.1038/s42003-022-03477-8 · Cited by 9
Metadata
- Authors
- Ahlert, J., Shepard, E., Lomovskaya, N., Zazopoulos, E., Staffa, A., Bachmann, B. O., Huang, K., Fonstein, L., Czisny, A., Whitwam, R. E., Farnet, C. M., & Thorson, J. S.
- Venue
- Science
- Published
- 2002-08-16
- Volume
- 297
- Issue
- 5584
- Pages
- 1173-1176
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2153554955
- Cited by
- 292
- References
- 0
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ahlert, J., Shepard, E., Lomovskaya, N., Zazopoulos, E., Staffa, A., Bachmann, B. O., Huang, K., Fonstein, L., Czisny, A., Whitwam, R. E., Farnet, C. M., & Thorson, J. S. (2002). The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS. Science. https://doi.org/10.1126/science.1072105
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