The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor
Abstract
Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)–anchored protein, whereas the MAG receptor has remained elusive. Here, we show that MAG binds directly, with high affinity, to NgR. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons are rendered MAG-sensitive by expression of NgR. MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury.
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Cites
Collins, B. E., Ito, H., Sawada, N., Ishida, H., Kiso, M., & Schnaar, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37637 · Cited by 73
Cited by
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Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1195 · Cited by 871
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
Wang, K. C., Kim, J. A., Sivasankaran, R., Segal, R., & He, Z. (2002) · Nature · doi:10.1038/nature01176 · Cited by 819
Rho kinase, a promising drug target for neurological disorders
Mueller, B. K., Mack, H., & Teusch, N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1719 · Cited by 608
PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration
Atwal, J. K., Pinkston-Gosse, J., Syken, J., Stawicki, S., Wu, Y., Shatz, C., & Tessier-Lavigne, M. (2008) · Science · doi:10.1126/science.1161151 · Cited by 502
Metadata
- Authors
- Liu, B. P., Fournier, A., GrandPré, T., & Strittmatter, S. M.
- Venue
- Science
- Published
- 2002-08-16
- Volume
- 297
- Issue
- 5584
- Pages
- 1190-1193
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1991539783
- Cited by
- 577
- References
- 1
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, B. P., Fournier, A., GrandPré, T., & Strittmatter, S. M. (2002). Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor. Science. https://doi.org/10.1126/science.1073031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
