The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Generation and in Vitro Differentiation of a Spermatogonial Cell Line
Open accessAbstract
Spermatogenesis is the process by which spermatogonial stem cells divide and differentiate to produce sperm. In vitro sperm production has been difficult to achieve because of the lack of a culture system to maintain viable spermatogonia for long periods of time. Here we report the in vitro generation of spermatocytes and spermatids from telomerase-immortalized mouse type A spermatogonial cells in the presence of stem cell factor. This differentiation can occur in the absence of supportive cells. The immortalized spermatogonial cell line may serve as a powerful tool in elucidating the molecular mechanisms of spermatogenesis. Furthermore, through genomic modification and transplantation techniques, this male germ cell line may be used to generate transgenic mice and to develop germ cell gene therapy.
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Cites
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Essential role of mouse telomerase in highly proliferative organs
Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270
Cited by
In vitro production of functional sperm in cultured neonatal mouse testes
Sato, T., Katagiri, K., Gohbara, A., Inoue, K., Ogonuki, N., Ogura, A., Kubota, Y., & Ogawa, T. (2011) · Nature · doi:10.1038/nature09850 · Cited by 746
Production of offspring from a germline stem cell line derived from neonatal ovaries
Zou, K., Yuan, Z., Yang, Z., Luo, H., Sun, K., Zhou, L., Xiang, J., Shi, L., Yu, Q., Zhang, Y., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1869 · Cited by 624
Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice
González-Suárez, E., Geserick, C., Flores, J. M., & Blasco, M. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208413 · Cited by 109
Metadata
- Authors
- Feng, L.-X., Chen, Y., Dettin, L., Pera, R. A. R., Herr, J. C., Goldberg, E., & Dym, M.
- Venue
- Science
- Published
- 2002-07-19
- Volume
- 297
- Issue
- 5580
- Pages
- 392-395
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031334250
- Cited by
- 258
- References
- 2
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Feng, L.-X., Chen, Y., Dettin, L., Pera, R. A. R., Herr, J. C., Goldberg, E., & Dym, M. (2002). Generation and in Vitro Differentiation of a Spermatogonial Cell Line. Science. https://doi.org/10.1126/science.1073162
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
