The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity
Abstract
A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1 , which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1 , which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1 , functions as the downstream MAP kinase required for pathogen defense. These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species.
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Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Cited by
Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., & Ichijo, H. (2005) · Nature Immunology · doi:10.1038/ni1200 · Cited by 667
Self-citationDiversity and versatility of p38 kinase signalling in health and disease
Canovas, B., & Nebreda, A. R. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00322-w · Cited by 657
Davis, J. M., Clay, H., Lewis, J. L., Ghori, N., Herbomel, P., & Ramakrishnan, L. (2002) · Immunity · doi:10.1016/s1074-7613(02)00475-2 · Cited by 565
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
De Haes, W., Frooninckx, L., Van Assche, R., Smolders, A., Depuydt, G., Billen, J., Braeckman, B. P., Schoofs, L., & Temmerman, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321776111 · Cited by 355
Bacterial pore-forming toxins: The (w)hole story?
Gonzalez, M. R., Bischofberger, M., Pernot, L., van der Goot, F. G., & Frêche, B. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7434-y · Cited by 262
Metadata
- Authors
- Kim, D. H., Feinbaum, R., Alloing, G., Emerson, F. E., Garsin, D. A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M.-W., & Ausubel, F. M.
- Venue
- Science
- Published
- 2002-07-26
- Volume
- 297
- Issue
- 5581
- Pages
- 623-626
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2104818214
- Cited by
- 853
- References
- 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, D. H., Feinbaum, R., Alloing, G., Emerson, F. E., Garsin, D. A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M.-W., & Ausubel, F. M. (2002). A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity. Science. https://doi.org/10.1126/science.1073759
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