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Nitrogenase MoFe-Protein at 1.16 Å Resolution: A Central Ligand in the FeMo-Cofactor
Abstract
A high-resolution crystallographic analysis of the nitrogenase MoFe-protein reveals a previously unrecognized ligand coordinated to six iron atoms in the center of the catalytically essential FeMo-cofactor. The electron density for this ligand is masked in structures with resolutions lower than 1.55 angstroms, owing to Fourier series termination ripples from the surrounding iron and sulfur atoms in the cofactor. The central atom completes an approximate tetrahedral coordination for the six iron atoms, instead of the trigonal coordination proposed on the basis of lower resolution structures. The crystallographic refinement at 1.16 angstrom resolution is consistent with this newly detected component being a light element, most plausibly nitrogen. The presence of a nitrogen atom in the cofactor would have important implications for the mechanism of dinitrogen reduction by nitrogenase.
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Cited by
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Hoffman, B. M., Lukoyanov, D., Yang, Z.-Y., Dean, D. R., & Seefeldt, L. C. (2014) · Chemical Reviews · doi:10.1021/cr400641x · Cited by 1,766
Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor
Spatzal, T., Aksoyoglu, M., Zhang, L., Andrade, S. L. A., Schleicher, E., Weber, S., Rees, D. C., & Einsle, O. (2011) · Science · doi:10.1126/science.1214025 · Cited by 914
Self-citationMolybdenum cofactors, enzymes and pathways
Schwarz, G., Mendel, R. R., & Ribbe, M. W. (2009) · Nature · doi:10.1038/nature08302 · Cited by 872
Elucidating reaction mechanisms on quantum computers
Reiher, M., Wiebe, N., Svore, K. M., Wecker, D., & Troyer, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619152114 · Cited by 745
Nitrogen fixation and hydrogen metabolism in cyanobacteria
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Metadata
- Authors
- Einsle, O., Tezcan, F. A., Andrade, S. L. A., Schmid, B., Yoshida, M., Howard, J. B., & Rees, D. C.
- Venue
- Science
- Published
- 2002-09-06
- Volume
- 297
- Issue
- 5587
- Pages
- 1696-1700
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986546695
- Cited by
- 1,093
- References
- 0
- FWCI
- 61.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Einsle, O., Tezcan, F. A., Andrade, S. L. A., Schmid, B., Yoshida, M., Howard, J. B., & Rees, D. C. (2002). Nitrogenase MoFe-Protein at 1.16 Å Resolution: A Central Ligand in the FeMo-Cofactor. Science. https://doi.org/10.1126/science.1073877
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