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Meiotic Arrest in the Mouse Follicle Maintained by a G s Protein in the Oocyte
Abstract
The mammalian ovarian follicle consists of a multilayered complex of somatic cells that surround the oocyte. A signal from the follicle cells keeps the oocyte cell cycle arrested at prophase of meiosis I until luteinizing hormone from the pituitary acts on the follicle cells to release the arrest, causing meiosis to continue. Here we show that meiotic arrest can be released in mice by microinjecting the oocyte within the follicle with an antibody that inhibits the stimulatory heterotrimeric GTP–binding protein G s . This indicates that G s activity in the oocyte is required to maintain meiotic arrest within the ovarian follicle and suggests that the follicle may keep the cell cycle arrested by activating G s .
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Citations
Cited by
Calcium at Fertilization and in Early Development
Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
Coticchio, G., Dal Canto, M., Mignini Renzini, M., Guglielmo, M. C., Brambillasca, F., Turchi, D., Novara, P. V., & Fadini, R. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv011 · Cited by 502
Sex Determination and Differentiation
MacLaughlin, D. T., & Donahoe, P. K. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022784 · Cited by 454
van den Hurk, R., & Zhao, J. (2005) · Theriogenology · doi:10.1016/j.theriogenology.2004.08.005 · Cited by 419
Albuz, F. K., Sasseville, M., Lane, M., Armstrong, D. T., Thompson, J. G., & Gilchrist, R. B. (2010) · Human Reproduction · doi:10.1093/humrep/deq246 · Cited by 284
Metadata
- Authors
- Mehlmann, L. M., Jones, T. L. Z., & Jaffe, L. A.
- Venue
- Science
- Published
- 2002-08-23
- Volume
- 297
- Issue
- 5585
- Pages
- 1343-1345
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969030895
- Cited by
- 237
- References
- 0
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Meiotic Arrest in the Mouse Follicle Maintained by a G s Protein in the Oocyte. https://app.cochat.ai/papers/10.1126/science.1073978
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- Mehlmann, L. M., Jones, T. L. Z., & Jaffe, L. A. (2002). Meiotic Arrest in the Mouse Follicle Maintained by a G s Protein in the Oocyte. Science. https://doi.org/10.1126/science.1073978
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