The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of ANC-1 in Tethering Nuclei to the Actin Cytoskeleton
Abstract
Mutations in anc-1 (nuclear anchorage defective) disrupt the positioning of nuclei and mitochondria in Caenorhabditis elegans . ANC-1 is shown to consist of mostly coiled regions with a nuclear envelope localization domain (called the KASH domain) and an actin-binding domain; this structure was conserved with the Drosophila protein Msp-300 and the mammalian Syne proteins. Antibodies against ANC-1 localized cytoplasmically and were enriched at the nuclear periphery in an UNC-84–dependent manner. Overexpression of the KASH domain or the actin-binding domain caused a dominant negative anchorage defect. Thus, ANC-1 may connect nuclei to the cytoskeleton by interacting with UNC-84 at the nuclear envelope and with actin in the cytoplasm.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
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Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 834
Haque, F., Lloyd, D. J., Smallwood, D. T., Dent, C. L., Shanahan, C. M., Fry, A. M., Trembath, R. C., & Shackleton, S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3738-3751.2006 · Cited by 503
Using Whole-Exome Sequencing to Identify Inherited Causes of Autism
Yu, T. W., Chahrour, M. H., Coulter, M. E., Jiralerspong, S., Okamura-Ikeda, K., Ataman, B., Schmitz-Abe, K., Harmin, D. A., Adli, M., Malik, A. N., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.002 · Cited by 442
Zhang, X., Lei, K., Yuan, X., Wu, X., Zhuang, Y., Xu, T., Xu, R., & Han, M. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.018 · Cited by 462
Self-citationLINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins
Sosa, B. A., Rothballer, A., Kutay, U., & Schwartz, T. U. (2012) · Cell · doi:10.1016/j.cell.2012.03.046 · Cited by 401
Metadata
- Authors
- Starr, D. A., & Han, M.
- Venue
- Science
- Published
- 2002-10-11
- Volume
- 298
- Issue
- 5592
- Pages
- 406-409
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062490010
- Cited by
- 402
- References
- 1
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
