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Membrane Effects of Thyrotropin-Releasing Hormone and Estrogen Shown by Intracellular Recording from Pituitary Cells
Abstract
The effects of thyrotropin-releasing hormone and 17 β-estradiol on the electrical membrane properties of a prolactin-secreting pituitary cell line (GH 3 /B6) were studied with intracellular microelectrode recordings. Of the cells tested, 50 percent were excitable and displayed calcium-dependent action potentials when depolarized. When injected directly on the membrane of an excitable cell, thyrotropin-releasing hormone and 17 β-estradiol induced action potentials within 1 minute. The spiking activity was preceded by a progressive increase of the input resistance without any detectable change in the resting membrane polarization. The results reveal a rapid effect of both substances on the membrane of GH 3 /B6 cells. In the case of thyrotropin-releasing hormone, which has both a short-term effect on release of prolactin and a long-term effect on its synthesis, the induced electrical activity may be associated with the stimulation of prolactin production. The physiological implication of 17 β-estradiol-induced, calcium-dependent spiking activity remains to be elucidated.
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Cited by
A new, nongenomic estrogen action: the rapid release of intracellular calcium
Morley, P. (1992) · Endocrinology · doi:10.1210/en.131.3.1305 · Cited by 391
Towle, A. C., & Sze, P. Y. (1983) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(83)90079-1 · Cited by 351
Zhou, Y., Watters, J. J., & Dorsa, D. M. (1996) · Endocrinology · doi:10.1210/en.137.5.2163 · Cited by 290
Duval, D., Durant, S., & Homo-Delarche, F. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90008-4 · Cited by 262
Emerging diversities in the mechanism of action of steroid hormones
Brann, D. W., Hendry, L. B., & Mahesh, V. B. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00160-n · Cited by 260
Metadata
- Authors
- Dufy, B., Vincent, J.-D., Fleury, H., Du Pasquier, P., Gourdji, D., & Tixier-Vidal, A.
- Venue
- Science
- Published
- 1979-05-04
- Volume
- 204
- Issue
- 4392
- Pages
- 509-511
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018964466
- Cited by
- 283
- References
- 0
- FWCI
- 23.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dufy, B., Vincent, J.-D., Fleury, H., Du Pasquier, P., Gourdji, D., & Tixier-Vidal, A. (1979). Membrane Effects of Thyrotropin-Releasing Hormone and Estrogen Shown by Intracellular Recording from Pituitary Cells. Science. https://doi.org/10.1126/science.107590
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