The DOI matches its Crossref record.
STAT1-Dependent Innate Immunity to a Norwalk-Like Virus
Abstract
Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1–dependent innate immunity, but not T and B cell–dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Updated classification of norovirus genogroups and genotypes
Chhabra, P., de Graaf, M., Parra, G. I., Chan, M. C.-W., Green, K., Martella, V., Wang, Q., White, P. A., Katayama, K., Vennema, H., et al. (2019) · Journal of General Virology · doi:10.1099/jgv.0.001318 · Cited by 895
Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases
Parrish, C. R., Holmes, E. C., Morens, D. M., Park, E.-C., Burke, D. S., Calisher, C. H., Laughlin, C. A., Saif, L. J., & Daszak, P. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00004-08 · Cited by 834
Bull, R. A., Tu, E. T. V., McIver, C. J., Rawlinson, W. D., & White, P. A. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.2.327-333.2006 · Cited by 344
Nlrp6 regulates intestinal antiviral innate immunity
Wang, P., Zhu, S., Yang, L., Cui, S., Pan, W., Jackson, R., Zheng, Y., Rongvaux, A., Sun, Q., Yang, G., et al. (2015) · Science · doi:10.1126/science.aab3145 · Cited by 304
Identification of RNA-Protein Interaction Networks Involved in the Norovirus Life Cycle
Vashist, S., Urena, L., Chaudhry, Y., & Goodfellow, I. (2012) · Journal of Virology · doi:10.1128/jvi.00432-12 · Cited by 78
Metadata
- Authors
- Karst, S. M., Wobus, C. E., Lay, M., Davidson, J., & Virgin, H. W.
- Venue
- Science
- Published
- 2003-03-07
- Volume
- 299
- Issue
- 5612
- Pages
- 1575-1578
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2158026372
- Cited by
- 816
- References
- 0
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: STAT1-Dependent Innate Immunity to a Norwalk-Like Virus. https://app.cochat.ai/papers/10.1126/science.1077905
- The paper
- Karst, S. M., Wobus, C. E., Lay, M., Davidson, J., & Virgin, H. W. (2003). STAT1-Dependent Innate Immunity to a Norwalk-Like Virus. Science. https://doi.org/10.1126/science.1077905
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
