The DOI matches its Crossref record.
Dispelling the Myths--Biocatalysis in Industrial Synthesis
Abstract
Biocatalysis has emerged as an important tool in the industrial synthesis of bulk chemicals, pharmaceutical and agrochemical intermediates, active pharmaceuticals, and food ingredients. However, the number and diversity of the applications are modest, perhaps in part because of perceived or real limitations of biocatalysts, such as limited enzyme availability, substrate scope, and operational stability. Recent scientific breakthroughs in genomics, directed enzyme evolution, and the exploitation of biodiversity should help to overcome these limitations. As a result, we expect many new industrial applications of biocatalysis to be realized, from single-step enzymatic conversions to customized multistep microbial synthesis by means of metabolic pathway engineering.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Directed evolution drives the next generation of biocatalysts
Turner, N. J. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.203 · Cited by 785
Biocatalysis for pharmaceutical intermediates: the future is now
Pollard, D. J., & Woodley, J. M. (2007) · Trends in Biotechnology · doi:10.1016/j.tibtech.2006.12.005 · Cited by 699
Barbosa, O., Torres, R., Ortiz, C., Berenguer-Murcia, Á., Rodrigues, R. C., & Fernandez-Lafuente, R. (2013) · Biomacromolecules · doi:10.1021/bm400762h · Cited by 494
Minimalist Active‐Site Redesign: Teaching Old Enzymes New Tricks
Toscano, M. D., Woycechowsky, K. J., & Hilvert, D. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604205 · Cited by 262
Dietrich, J. A., Yoshikuni, Y., Fisher, K. J., Woolard, F. X., Ockey, D., McPhee, D. J., Renninger, N. S., Chang, M. C. Y., Baker, D., & Keasling, J. D. (2009) · ACS Chemical Biology · doi:10.1021/cb900006h · Cited by 186
Metadata
- Authors
- Schoemaker, H. E., Mink, D., & Wubbolts, M. G.
- Venue
- Science
- Published
- 2003-03-14
- Volume
- 299
- Issue
- 5613
- Pages
- 1694-1697
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2154998149
- Cited by
- 834
- References
- 0
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dispelling the Myths--Biocatalysis in Industrial Synthesis. https://app.cochat.ai/papers/10.1126/science.1079237
- The paper
- Schoemaker, H. E., Mink, D., & Wubbolts, M. G. (2003). Dispelling the Myths--Biocatalysis in Industrial Synthesis. Science. https://doi.org/10.1126/science.1079237
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
