The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling
Abstract
We investigated the forces that connect the genetic program of development to morphogenesis in Drosophila . We focused on dorsal closure, a powerful model system for development and wound healing. We found that the bulk of progress toward closure is driven by contractility in supracellular “purse strings” and in the amnioserosa, whereas adhesion-mediated zipping coordinates the forces produced by the purse strings and is essential only for the end stages. We applied quantitative modeling to show that these forces, generated in distinct cells, are coordinated in space and synchronized in time. Modeling of wild-type and mutant phenotypes is predictive; although closure in myospheroid mutants ultimately fails when the cell sheets rip themselves apart, our analysis indicates that β PS integrin has an earlier, important role in zipping.
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Cites
Purcell, E. M. (1977) · American Journal of Physics · doi:10.1119/1.10903 · Cited by 4,360
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Ladoux, B., & Mège, R.-M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.98 · Cited by 749
Force Generation, Transmission, and Integration during Cell and Tissue Morphogenesis
Lecuit, T., Lenne, P.-F., & Munro, E. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104027 · Cited by 621
Cell-ECM traction force modulates endogenous tension at cell–cell contacts
Maruthamuthu, V., Sabass, B., Schwarz, U. S., & Gardel, M. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011123108 · Cited by 520
Apical constriction: A cell shape change that can drive morphogenesis
Sawyer, J. M., Harrell, J. R., Shemer, G., Sullivan-Brown, J., Roh-Johnson, M., & Goldstein, B. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.009 · Cited by 448
Metadata
- Authors
- Hutson, M. S., Tokutake, Y., Chang, M.-S., Bloor, J. W., Venakides, S., Kiehart, D. P., & Edwards, G. S.
- Venue
- Science
- Published
- 2003-04-04
- Volume
- 300
- Issue
- 5616
- Pages
- 145-149
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2146835460
- Cited by
- 528
- References
- 1
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hutson, M. S., Tokutake, Y., Chang, M.-S., Bloor, J. W., Venakides, S., Kiehart, D. P., & Edwards, G. S. (2003). Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling. Science. https://doi.org/10.1126/science.1079552
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
