The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility
Abstract
Loss of CD2-associated protein (CD2AP), a component of the filtration complex in the kidney, causes death in mice at 6 weeks of age. Mice with CD2AP haploinsufficiency developed glomerular changes at 9 months of age and had increased susceptibility to glomerular injury by nephrotoxic antibodies or immune complexes. Electron microscopic analysis of podocytes revealed defects in the formation of multivesicular bodies, suggesting an impairment of the intracellular degradation pathway. Two human patients with focal segmental glomerulosclerosis had a mutation predicted to ablate expression of one CD2AP allele, implicating CD2AP as a determinant of human susceptibility to glomerular disease.
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Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.-C., Niaudet, P., & Antignac, C. (2000) · Nature Genetics · doi:10.1038/74166 · Cited by 1,444
Cited by
The podocyte’s response to injury: role in proteinuria and glomerulosclerosis
Shankland, S. J. (2006) · Kidney International · doi:10.1038/sj.ki.5000410 · Cited by 846
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
Morita, E., Sandrin, V., Chung, H., Morham, S. G., Gygi, S. P., Rodesch, C. K., & Sundquist, W. I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601850 · Cited by 724
Hinkes, B. G., Mucha, B., Vlangos, C. N., Gbadegesin, R., Liu, J., Hasselbacher, K., Hangan, D., Ozaltin, F., Zenker, M., Hildebrandt, F., et al. (2007) · Pediatrics · doi:10.1542/peds.2006-2164 · Cited by 444
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
Weavers, H., Prieto-Sánchez, S., Grawe, F., Garcia-López, A., Artero, R., Wilsch-Bräuninger, M., Ruiz-Gómez, M., Skaer, H., & Denholm, B. (2009) · Nature · doi:10.1038/nature07526 · Cited by 331
The podocyte slit diaphragm--from a thin grey line to a complex signalling hub
Grahammer, F., Schell, C., & Huber, T. B. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.169 · Cited by 269
Metadata
- Authors
- Kim, J. M., Wu, H., Green, G., Winkler, C. A., Kopp, J. B., Miner, J. H., Unanue, E. R., & Shaw, A. S.
- Venue
- Science
- Published
- 2003-05-23
- Volume
- 300
- Issue
- 5623
- Pages
- 1298-1300
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031098987
- Cited by
- 513
- References
- 1
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility. https://app.cochat.ai/papers/10.1126/science.1081068
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- Kim, J. M., Wu, H., Green, G., Winkler, C. A., Kopp, J. B., Miner, J. H., Unanue, E. R., & Shaw, A. S. (2003). CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility. Science. https://doi.org/10.1126/science.1081068
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
