The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis
Abstract
BAX and BAK are “multidomain” proapoptotic proteins that initiate mitochondrial dysfunction but also localize to the endoplasmic reticulum (ER). Mouse embryonic fibroblasts deficient for BAX and BAK (DKO cells) were found to have a reduced resting concentration of calcium in the ER ([Ca 2+ ] er ) that results in decreased uptake of Ca 2+ by mitochondria after Ca 2+ release from the ER. Expression of SERCA (sarcoplasmic-endoplasmic reticulum Ca 2+ adenosine triphosphatase) corrected [Ca 2+ ] er and mitochondrial Ca 2+ uptake in DKO cells, restoring apoptotic death in response to agents that release Ca 2+ from intracellular stores (such as arachidonic acid, C 2 -ceramide, and oxidative stress). In contrast, targeting of BAX to mitochondria selectively restored apoptosis to “BH3-only” signals. A third set of stimuli, including many intrinsic signals, required both ER-released Ca 2+ and the presence of mitochondrial BAX or BAK to fully restore apoptosis. Thus, BAX and BAK operate in both the ER and mitochondria as an essential gateway for selected apoptotic signals.
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Citations
Cites
Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses
Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., & Pozzan, T. (1998) · Science · doi:10.1126/science.280.5370.1763 · Cited by 2,257
Self-citation
Cited by
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationDanial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Self-citationMitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
The Pathophysiology of Mitochondrial Cell Death
Green, D. R., & Kroemer, G. (2004) · Science · doi:10.1126/science.1099320 · Cited by 3,418
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575
Metadata
- Authors
- Scorrano, L., Oakes, S. A., Opferman, J. T., Cheng, E. H., Sorcinelli, M. D., Pozzan, T., & Korsmeyer, S. J.
- Venue
- Science
- Published
- 2003-04-04
- Volume
- 300
- Issue
- 5616
- Pages
- 135-139
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054820743
- Cited by
- 1,385
- References
- 1
- FWCI
- 36.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Scorrano, L., Oakes, S. A., Opferman, J. T., Cheng, E. H., Sorcinelli, M. D., Pozzan, T., & Korsmeyer, S. J. (2003). BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis. Science. https://doi.org/10.1126/science.1081208
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