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Roles of NPM2 in Chromatin and Nucleolar Organization in Oocytes and Embryos
Abstract
Upon fertilization, remodeling of condensed maternal and paternal gamete DNA occurs to form the diploid genome. In Xenopus laevis , nucleoplasmin 2 (NPM2) decondenses sperm DNA in vitro. To study chromatin remodeling in vivo, we isolated mammalian NPM2 orthologs. Mouse NPM2 accumulates in oocyte nuclei and persists in preimplantation embryos. Npm2 knockout females have fertility defects owing to failed preimplantation embryo development. Although sperm DNA decondensation proceeds without NPM2, abnormalities are evident in oocyte and early embryonic nuclei. These defects include an absence of coalesced nucleolar structures and loss of heterochromatin and deacetylated histone H3 that normally circumscribe nucleoli in oocytes and early embryos, respectively. Thus, Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development.
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Cited by
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Genetic and Epigenetic Regulators of Pluripotency
Surani, M. A., Hayashi, K., & Hajkova, P. (2007) · Cell · doi:10.1016/j.cell.2007.02.010 · Cited by 658
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Li, L., Zheng, P., & Dean, J. (2010) · Development · doi:10.1242/dev.039487 · Cited by 481
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
Eckersley-Maslin, M. A., Alda-Catalinas, C., & Reik, W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0008-z · Cited by 431
Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells
Falco, G., Lee, S.-L., Stanghellini, I., Bassey, U. C., Hamatani, T., & Ko, M. S. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.003 · Cited by 306
Metadata
- Authors
- Burns, K. H., Viveiros, M. M., Ren, Y., Wang, P., DeMayo, F. J., Frail, D. E., Eppig, J. J., & Matzuk, M. M.
- Venue
- Science
- Published
- 2003-04-25
- Volume
- 300
- Issue
- 5619
- Pages
- 633-636
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142965179
- Cited by
- 361
- References
- 0
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burns, K. H., Viveiros, M. M., Ren, Y., Wang, P., DeMayo, F. J., Frail, D. E., Eppig, J. J., & Matzuk, M. M. (2003). Roles of NPM2 in Chromatin and Nucleolar Organization in Oocytes and Embryos. Science. https://doi.org/10.1126/science.1081813
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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