Genetics and the Specificity of the Aging Process
Abstract
The identification and study of long-lived mutant animals has provided valuable insights into the mechanisms that limit the life-span of organisms. Findings with the gene SIR2 suggest that the rate of aging can be regulated under certain conditions. Indeed, increased expression of SIR2 lengthens life-span by acting on biological processes that promote survival under conditions of scarcity. In addition, studies of mutant strains of Caenorhabditis elegans , in particular daf-2 , clk-1 , and isp-1 mutants, suggest that the biology of reactive oxygen species in the mitochondria and elsewhere might be the main determinant of life-span in this organism. Thus, the aging process may be more specific than previously anticipated on evolutionary grounds.
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Aging is a genetically regulated process defined by progressive decline of somatic cell functions with age.
“Aging is a genetically regulated process that is defined by progressive decline of somatic cell functions with age (46, 70).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [70]
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References 59 · Cited by 434
- Authors
- Hekimi, S., & Guarente, L.
- Affiliations
- McGill University (CA)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Hekimi, Siegfried
- Venue
- Science
- Published
- 2003-02-28
- Volume
- 299
- Issue
- 5611
- Pages
- 1351-1354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993504110
- Cited by
- 434
- References
- 59
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 3 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 15
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, longevity, Sir2, lifespan regulation, Caenorhabditis elegans, daf-2, clk-1, isp-1, reactive oxygen species, mitochondrial biology
- MeSH terms
- Aging, Animals, Gene Expression Regulation, Histone Deacetylases, Iron-Sulfur Proteins, Longevity, Mitochondria, Mutation, Receptor, Insulin, Saccharomyces cerevisiae, Electron Transport Complex III, Helminth Proteins, Caenorhabditis elegans, Reactive Oxygen Species, Caenorhabditis elegans Proteins, Sirtuins
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