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Boon and Bane of Metal Ions in Medicine
Abstract
In biological systems metal ions promote responses that range from deficiency to toxicity. Some, such as iron and zinc, have a known optimal intake range for normal, healthy individuals. Metal ions contained within well-designed molecules already constitute a great boon for the medicinal pharmacopoeia. However, whether essential or not, the threshold for toxicity can be very low. One of the challenges of designing metal-based drugs is to balance the potential toxicity of an active formulation with the substantial positive impact of these increasingly common therapeutic and diagnostic aids.
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Cited by
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Andreini, C., Banci, L., Bertini, I., & Rosato, A. (2006) · Journal of Proteome Research · doi:10.1021/pr050361j · Cited by 1,109
Using coordination chemistry to design new medicines
Ronconi, L., & Sadler, P. J. (2007) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2006.11.017 · Cited by 608
Bioinorganics and biomaterials: Bone repair
Habibovic, P., & Barralet, J. E. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.03.027 · Cited by 441
Xiao, Z., Loughlin, F., George, G. N., Howlett, G. J., & Wedd, A. G. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0390350 · Cited by 255
Ling, J., Shen, J., & Hogen-Esch, T. E. (2009) · Polymer · doi:10.1016/j.polymer.2009.06.006 · Cited by 58
Metadata
- Authors
- Thompson, K. H., & Orvig, C.
- Venue
- Science
- Published
- 2003-05-09
- Volume
- 300
- Issue
- 5621
- Pages
- 936-939
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997326839
- Cited by
- 424
- References
- 0
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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