The DOI matches its Crossref record.
Derivation of Oocytes from Mouse Embryonic Stem Cells
Abstract
Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation.
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Citations
Cited by
Resurrecting biodiversity: Advanced assisted reproductive technologies and biobanking
Bolton, R. L., Mooney, A., Pettit, M. T., Bolton, A. E., Morgan, L., Drake, G. J., Appeltant, R., Walker, S. L., Gillis, J. D., & Hvilsom, C. (2022) · Reproduction and Fertility · doi:10.1530/raf-22-0005 · Cited by 108
Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit
Sparrow, R. (2022) · The American Journal of Bioethics · doi:10.1080/15265161.2021.1907480 · Cited by 40
Metadata
- Authors
- Hübner, K., Fuhrmann, G., Christenson, L. K., Kehler, J., Reinbold, R., De La Fuente, R., Wood, J., Strauss, J. F., Boiani, M., & Schöler, H. R.
- Venue
- Science
- Published
- 2003-05-23
- Volume
- 300
- Issue
- 5623
- Pages
- 1251-1256
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977135603
- Cited by
- 1,075
- References
- 0
- FWCI
- 96.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Derivation of Oocytes from Mouse Embryonic Stem Cells. https://app.cochat.ai/papers/10.1126/science.1083452
- The paper
- Hübner, K., Fuhrmann, G., Christenson, L. K., Kehler, J., Reinbold, R., De La Fuente, R., Wood, J., Strauss, J. F., Boiani, M., & Schöler, H. R. (2003). Derivation of Oocytes from Mouse Embryonic Stem Cells. Science. https://doi.org/10.1126/science.1083452
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
