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Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo
Abstract
The use of semiconductor nanocrystals (quantum dots) as fluorescent labels for multiphoton microscopy enables multicolor imaging in demanding biological environments such as living tissue. We characterized water-soluble cadmium selenide–zinc sulfide quantum dots for multiphoton imaging in live animals. These fluorescent probes have two-photon action cross sections as high as 47,000 Goeppert-Mayer units, by far the largest of any label used in multiphoton microscopy. We visualized quantum dots dynamically through the skin of living mice, in capillaries hundreds of micrometers deep. We found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales.
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Cited by
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Carbon quantum dots and their applications
Lim, S. Y., Shen, W., & Gao, Z. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00269e · Cited by 4,976
Luminescent Carbon Nanodots: Emergent Nanolights
Baker, S. N., & Baker, G. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906623 · Cited by 4,921
Probing the Cytotoxicity of Semiconductor Quantum Dots
Derfus, A. M., Chan, W. C. W., & Bhatia, S. N. (2004) · Nano Letters · doi:10.1021/nl0347334 · Cited by 3,391
Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014) · Advanced Materials · doi:10.1002/adma.201401356 · Cited by 3,381
Metadata
- Authors
- Larson, D. R., Zipfel, W. R., Williams, R. M., Clark, S. W., Bruchez, M. P., Wise, F. W., & Webb, W. W.
- Venue
- Science
- Published
- 2003-05-30
- Volume
- 300
- Issue
- 5624
- Pages
- 1434-1436
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015622350
- Cited by
- 2,286
- References
- 0
- FWCI
- 64.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Larson, D. R., Zipfel, W. R., Williams, R. M., Clark, S. W., Bruchez, M. P., Wise, F. W., & Webb, W. W. (2003). Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo. Science. https://doi.org/10.1126/science.1083780
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