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Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR
Abstract
The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10 – 21 molar) sensitivity to free Cu + , which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn 2 + -sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
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Citations
Cites
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
Outten, C. E., & O'Halloran, A. T. V. (2001) · Science · doi:10.1126/science.1060331 · Cited by 1,489
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Cited by
Antimicrobial activity of metals: mechanisms, molecular targets and applications
Lemire, J. A., Harrison, J. J., & Turner, R. J. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3028 · Cited by 2,746
Metalloproteins and metal sensing
Waldron, K. J., Rutherford, J. C., Ford, D., & Robinson, N. J. (2009) · Nature · doi:10.1038/nature08300 · Cited by 1,269
Counting the Zinc-Proteins Encoded in the Human Genome
Andreini, C., Banci, L., Bertini, I., & Rosato, A. (2006) · Journal of Proteome Research · doi:10.1021/pr050361j · Cited by 1,109
How do bacterial cells ensure that metalloproteins get the correct metal?
Waldron, K. J., & Robinson, N. J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2057 · Cited by 834
Specific interactions between silver(i) ions and cytosine–cytosine pairs in DNA duplexes
Ono, A., Cao, S., Togashi, H., Tashiro, M., Fujimoto, T., Machinami, T., Oda, S., Miyake, Y., Okamoto, I., & Tanaka, Y. (2008) · Chemical Communications · doi:10.1039/b808686a · Cited by 771
Metadata
- Authors
- Changela, A., Chen, K., Xue, Y., Holschen, J., Outten, C. E., O'Halloran, T. V., & Mondragón, A.
- Venue
- Science
- Published
- 2003-09-05
- Volume
- 301
- Issue
- 5638
- Pages
- 1383-1387
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995732138
- Cited by
- 660
- References
- 1
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Changela, A., Chen, K., Xue, Y., Holschen, J., Outten, C. E., O'Halloran, T. V., & Mondragón, A. (2003). Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR. Science. https://doi.org/10.1126/science.1085950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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