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A Conserved Domain in Axonal Targeting of Kv1 (Shaker) Voltage-Gated Potassium Channels
Abstract
Axonal voltage-gated potassium (Kv1) channels regulate action-potential invasion and hence transmitter release. Although evolutionarily conserved, what mediates their axonal targeting is not known. We found that Kv1 axonal targeting required its T1 tetramerization domain. When fused to unpolarized CD4 or dendritic transferrin receptor, T1 promoted their axonal surface expression. Moreover, T1 mutations eliminating Kvβ association compromised axonal targeting, but not surface expression, of CD4-T1 fusion proteins. Thus, proper association of Kvβ with the Kv1 T1 domain is essential for axonal targeting.
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Citations
Cited by
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Hirokawa, N., & Takemura, R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1624 · Cited by 834
Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons
Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488
The distribution and targeting of neuronal voltage-gated ion channels
Lai, H. C., & Jan, L. Y. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1938 · Cited by 468
Self-citationInformation processing in the axon
Debanne, D. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1397 · Cited by 400
Chen, X., Yuan, L.-L., Zhao, C., Birnbaum, S. G., Frick, A., Jung, W. E., Schwarz, T. L., Sweatt, J. D., & Johnston, D. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2667-06.2006 · Cited by 309
Metadata
- Authors
- Gu, C., Jan, Y. N., & Jan, L. Y.
- Venue
- Science
- Published
- 2003-08
- Volume
- 301
- Issue
- 5633
- Pages
- 646-649
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1664511950
- Cited by
- 160
- References
- 0
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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