Persistence Without Pathology in Phosphoglycan-Deficient Leishmania major
Abstract
Leishmania infections involve an acute phase of replication within macrophages, typically associated with pathology. After recovery parasites persist for long periods, which can lead to severe disease upon reactivation. Unlike the role of host factors, parasite factors affecting persistence are poorly understood. Leishmania major lacking phosphoglycans ( lpg2 - ) were unable to survive in sand flies and macrophages, but retained the ability to persist indefinitely in the mammalian host without inducing disease. The L. major lpg2 - thus provides a platform for probing parasite factors implicated in persistence and its role in disease and immunity.
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Lipophosphoglycan of Leishmania species is needed for establishment of initial infections in vertebrate hosts, and not for persistence or pathology, but is later needed for binding to galectins located on the surface of midguts of their invertebrate vectors.
“An example is the lipophosphoglycan of Leishmania species, which is needed for establishment of initial infections in vertebrate hosts, and not for persistence or pathology (1006) --but is later needed for binding to galectins located on the surface of midguts of their invertebrate vectors (1007).”
From Biological roles of glycans (2017) · cites this paper as [1006]
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References 29 · Cited by 167
- Authors
- Späth, G. F., Lye, L.-F., Segawa, H., Sacks, D. L., Turco, S. J., & Beverley, S. M.
- Affiliations
- Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA. Department of Biochemistry, University of Kentucky Medical School, Lexington KY 40536, USA. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
- University of Kentucky (US)
- Corresponding author
- Beverley, Stephen M.
- Venue
- Science
- Published
- 2003-08-29
- Volume
- 301
- Issue
- 5637
- Pages
- 1241-1243
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968292510
- Cited by
- 167
- References
- 29
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 7
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI31078, R01AI031078)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
- Keywords
- Leishmania major, phosphoglycans, parasite persistence, chronic infection, sand flies, macrophages, disease reactivation, host-parasite interactions, parasite survival
- MeSH terms
- Animals, Complement System Proteins, Female, Glycosphingolipids, Host-Parasite Interactions, Humans, Insect Vectors, Macrophage Activation, Macrophages, Membrane Proteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Mutation, Nitric Oxide, Phagosomes, Phlebotomus, Virulence, Protozoan Proteins, Cytokines, Leishmaniasis, Cutaneous, Leishmania major, Mice
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