The DOI matches its Crossref record.
Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome
Abstract
Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balance between stem cell self-renewal and differentiation is poorly understood. Here, we show that dividing Drosophila male germline stem cells use intracellular mechanisms involving centrosome function and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitotic spindles perpendicular to the niche, ensuring a reliably asymmetric outcome in which one daughter cell remains in the niche and self-renews stem cell identity, whereas the other, displaced away, initiates differentiation.
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Cited by
Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
Adherens junctions: from molecules to morphogenesis
Harris, T. J. C., & Tepass, U. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2927 · Cited by 990
Hochedlinger, K., Yamada, Y., Beard, C., & Jaenisch, R. (2005) · Cell · doi:10.1016/j.cell.2005.02.018 · Cited by 747
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Metadata
- Authors
- Yamashita, Y. M., Jones, D. L., & Fuller, M. T.
- Venue
- Science
- Published
- 2003-09-12
- Volume
- 301
- Issue
- 5639
- Pages
- 1547-1550
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086265207
- Cited by
- 738
- References
- 0
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
