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A Four-Base Paired Genetic Helix with Expanded Size
Abstract
We describe a new molecular class of genetic-pairing system that has a native DNA backbone but has all four base pairs replaced by new, larger pairs. The base pairs include size-expanded analogs of thymine and of adenine, both extended by the width of a benzene ring (2.4 Å). The expanded-diameter double helices are more thermodynamically stable than the Watson-Crick helix, likely because of enhanced base stacking. Structural data confirm a right-handed, double-stranded, and base-paired helical form. Because of the larger base size, all the pairs of this helical system are fluorescent, which suggests practical applications in detection of natural DNA and RNA. Our findings establish that there is no apparent structural or thermodynamic prohibition against genetic systems having sizes different from the natural one.
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Cites
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Chemical etiology of nucleic acid structure
Eschenmoser, A. (1999) · Science · doi:10.1126/science.284.5423.2118 · Cited by 611
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Das, R., & Baker, D. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062906.171838 · Cited by 989
C-Nucleosides: Synthetic Strategies and Biological Applications
Hocek, M. (2009) · Chemical Reviews · doi:10.1021/cr9002165 · Cited by 383
Stacked–Unstacked Equilibrium at the Nick Site of DNA
Protozanova, E., Yakovchuk, P., & Frank-Kamenetskii, M. D. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.07.075 · Cited by 259
Metadata
- Authors
- Liu, H., Gao, J., Lynch, S. R., Saito, Y. D., Maynard, L., & Kool, E. T.
- Venue
- Science
- Published
- 2003-10-31
- Volume
- 302
- Issue
- 5646
- Pages
- 868-871
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021167468
- Cited by
- 227
- References
- 2
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, H., Gao, J., Lynch, S. R., Saito, Y. D., Maynard, L., & Kool, E. T. (2003). A Four-Base Paired Genetic Helix with Expanded Size. Science. https://doi.org/10.1126/science.1088334
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