The DOI matches its Crossref record.
Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses
Abstract
Mammals can be trained to make a conditioned movement at a precise time, which is correlated to the interval between the conditioned stimulus and unconditioned stimulus during the learning. This learning-dependent timing has been shown to depend on an intact cerebellar cortex, but which cellular process is responsible for this form of learning remains to be demonstrated. Here, we show that protein kinase C–dependent long-term depression in Purkinje cells is necessary for learning-dependent timing of Pavlovian-conditioned eyeblink responses.
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Citations
Cited by
Cerebellar circuitry as a neuronal machine
Ito, M. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.02.006 · Cited by 880
The Neuroscience of Mammalian Associative Learning
Fanselow, M. S., & Poulos, A. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070213 · Cited by 683
Consensus Paper: The Role of the Cerebellum in Perceptual Processes
Baumann, O., Borra, R. J., Bower, J. M., Cullen, K. E., Habas, C., Ivry, R. B., Leggio, M., Mattingley, J. B., Molinari, M., Moulton, E. A., et al. (2015) · The Cerebellum · doi:10.1007/s12311-014-0627-7 · Cited by 462
Cerebellum-dependent learning: the role of multiple plasticity mechanisms
Boyden, E. S., Katoh, A., & Raymond, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144238 · Cited by 448
Steinberg, J. P., Takamiya, K., Shen, Y., Xia, J., Rubio, M. E., Yu, S., Jin, W., Thomas, G. M., Linden, D. J., & Huganir, R. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.025 · Cited by 288
Metadata
- Authors
- Koekkoek, S. K. E., Hulscher, H. C., Dortland, B. R., Hensbroek, R. A., Elgersma, Y., Ruigrok, T. J. H., & De Zeeuw, C. I.
- Venue
- Science
- Published
- 2003-09-19
- Volume
- 301
- Issue
- 5640
- Pages
- 1736-1739
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010753031
- Cited by
- 263
- References
- 0
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koekkoek, S. K. E., Hulscher, H. C., Dortland, B. R., Hensbroek, R. A., Elgersma, Y., Ruigrok, T. J. H., & De Zeeuw, C. I. (2003). Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses. Science. https://doi.org/10.1126/science.1088383
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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