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Abnormal Coronary Function in Mice Deficient in α 1H T-type Ca 2+ Channels
Abstract
Calcium ion (Ca 2+ ) influx through voltage-gated Ca 2+ channels is important for the regulation of vascular tone. Activation of L-type Ca 2+ channels initiates muscle contraction; however, the role of T-type Ca 2+ channels (T-channels) is not clear. We show that mice deficient in the α 1H T-type Ca 2+ channel (α 1 3.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from α 1 3.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni 2+ prevented relaxation of wild-type coronary arteries. Thus, Ca 2+ influx through α 1H T-type Ca 2+ channels is essential for normal relaxation of coronary arteries.
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Citations
Cited by
Zamponi, G. W., Striessnig, J., Koschak, A., & Dolphin, A. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009654 · Cited by 1,103
Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction
Simms, B. A., & Zamponi, G. W. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.016 · Cited by 675
Genesis and Regulation of the Heart Automaticity
Mangoni, M. E., & Nargeot, J. (2008) · Physiological Reviews · doi:10.1152/physrev.00018.2007 · Cited by 600
Bourinet, E., Alloui, A., Monteil, A., Barrère, C., Couette, B., Poirot, O., Pages, A., McRory, J., Snutch, T. P., Eschalier, A., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600515 · Cited by 461
Calcium–calcineurin signaling in the regulation of cardiac hypertrophy
Wilkins, B. J., & Molkentin, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.121 · Cited by 440
Metadata
- Authors
- Chen, C.-C., Lamping, K. G., Nuno, D. W., Barresi, R., Prouty, S. J., Lavoie, J. L., Cribbs, L. L., England, S. K., Sigmund, C. D., Weiss, R. M., Williamson, R. A., Hill, J. A., & Campbell, K. P.
- Venue
- Science
- Published
- 2003-11-21
- Volume
- 302
- Issue
- 5649
- Pages
- 1416-1418
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2110993458
- Cited by
- 336
- References
- 0
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, C.-C., Lamping, K. G., Nuno, D. W., Barresi, R., Prouty, S. J., Lavoie, J. L., Cribbs, L. L., England, S. K., Sigmund, C. D., Weiss, R. M., Williamson, R. A., Hill, J. A., & Campbell, K. P. (2003). Abnormal Coronary Function in Mice Deficient in α 1H T-type Ca 2+ Channels. Science. https://doi.org/10.1126/science.1089268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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