Glucagon: Role in the Hyperglycemia of Diabetes Mellitus

Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., Unger, R.·1975·Science
DOI 10.1126/science.1089999

Cited by (235)

Items 101–200 of 235

  1. Choline Supplementation Promotes Hepatic Insulin Resistance in Phosphatidylethanolamine N-Methyltransferase-deficient Mice via Increased Glucagon Action
    Gengshu Wu, Liyan Zhang, Tete Li, Azeret Zuniga, Gary D. Lopaschuk, Liang Li, René L. Jacobs, Dennis E. Vance · 2012 · Journal of Biological Chemistry
  2. Human Glucagon Receptor Antagonists with Thiazole Cores. A Novel Series with Superior Pharmacokinetic Properties
    Peter Madsen, János T. Kodra, Carsten Behrens, Erica Nishimura, Claus Bekker Jeppesen, Lone Pridal, Birgitte Andersen, Lotte Bjerre Knudsen, Carmen Valcarce-Aspegren, Mette Guldbrandt et al. · 2009 · Journal of Medicinal Chemistry
  3. Plasma glucagon immunoreactivity in a totally pancreatectomized patient
    María Luisa Villanueva, JOSE A. HEDO, J. Marco · 1976 · Diabetologia
  4. Somatostatin
    Wylie Vale, Paul Brazeau, CATHERINE L. RIVIER, Marvin Brown, Barbara D. Boss, Jean Rivier, Roger Cecil Burgus, NICHOLAS C. LING, Roger Guillemin · 1975 · Elsevier eBooks
  5. The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression
    Bin Yan, Xurui Li, Mou Peng, Yali Zuo, Yinhuai Wang, Pian Liu, Weigang Ren, Xin Jin · 2023 · Experimental & Molecular Medicine
  6. Flavone Hispidulin Stimulates Glucagon‐Like Peptide‐1 Secretion and Ameliorates Hyperglycemia in Streptozotocin‐Induced Diabetic Mice
    Yao Wang, Aiping Wang, Hana Alkhalidy, Jing Luo, Elizabeth Moomaw, Andrew Peter Neilson, Dongmin Liu · 2020 · Molecular Nutrition & Food Research
  7. Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia
    Thomas H. Meek, Mauricio D. Dorfman, Miles E. Matsen, Jonathan D. Fischer, Alex Cubelo, Monica R. Kumar, Gerald J. Taborsky, Gregory J. Morton · 2015 · Diabetes
  8. Antisense Oligonucleotides as Potential Therapeutics for Type 2 Diabetes
    Suxiang Chen, Nabayet Sbuh, Rakesh Naduvile Veedu · 2020 · Nucleic Acid Therapeutics
  9. Evaluating diabetic ketoacidosis via a MOF sensor for fluorescence imaging of phosphate and pH
    Xue Wang, Jin Li, Wei Zhang, Ping Li, Wen Zhang, Hui Wang, Bo Tang · 2022 · Chemical Communications
  10. Effects of caerulein and bombesin on insulin and glucagon secretion from the isolated, perfused rat pancreas
    Robert G. Martindale, Seymour R. Levin, Roslyn B. Alfin‐Slater · 1982 · Regulatory Peptides
  11. Subclinical Diabetes
    Luís Maurício T. R. Lima · 2017 · Anais da Academia Brasileira de Ciências
  12. Non-Essential Role of Dietary Factors in the Development of Diabetes in ob/ob Mice
    Paul U. Dubuc · 1981 · Journal of Nutrition
  13. Extrapancreatic glucagon in the dog
    M. Vranić, Ronald L. Engerman, Kazuteru Doi, S. Morita, Christopher Yip · 1976 · Metabolism
  14. A combined radioimmunoassay for glucagon and insulin
    Viviane Leclercq-Meyer, J. Marchand, Oscar R. Rebolledo, Willy Jean Malaisse, Raoul Leclercq · 1975 · Diabetologia
  15. Salivary gland glucagon in man and animals
    A. M. Lawrence, S. Tan, Sally Hojvat, Lidia Kirsteins, Jan Mitton · 1976 · Metabolism
  16. Neutralization of Glucagon by Antiserum as a Tool in Glucagon Physiology
    Jens Juul Holst, H. Galbo, Erik Arne Richter · 1978 · Journal of Clinical Investigation
  17. Endocrine pancreatic cells of postatal “diabetes” (DB) mice in cell culture
    Edward H. Leiter, Douglas L. Coleman, John J. Eppig · 1979 · In Vitro Cellular & Developmental Biology - Plant
  18. Glucagon and glicentin immunoreactive cells in human colon
    Pamela C. Colony, Volker Helmstaedter, A.J. Moody, J.C. Garaud, W. G. Forssmann · 1982 · Cell and Tissue Research
  19. Hyperglycemia triggers HIPK2 protein degradation
    Silvia Baldari, Alessia Garufi, Marisa Granato, Laura Cuomo, Giuseppa Pistritto, Mara Cirone, Gabriella D’Orazi · 2016 · Oncotarget
  20. The Pathology of Juvenile Diabetes
    Philip M. LeCompte, Willy Gepts · 1977 · Springer eBooks
  21. Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes
    Masaki Kobayashi, Hiroaki Satoh, Toshihiro Matsuo, Yoshiki Kusunoki, Masahiko Tokushima, Hirotaka Watada, Mitsuyoshi Namba, Tadahiro Kitamura · 2020 · Endocrine Journal
  22. Effects of selective insulin or glucagon deficiency on glucose turnover.
    H.Lavina A. Lickley, G G Ross, M. Vranić · 1979 · American Journal of Physiology-Endocrinology and Metabolism
  23. Role of Melanocortin Signaling in Neuroendocrine and Metabolic Actions of Leptin in Male Rats With Uncontrolled Diabetes
    Thomas H. Meek, Miles E. Matsen, Vincent M. Damian, Alex Cubelo, Streamson C. Chua, Gregory J. Morton · 2014 · Endocrinology
  24. Dietary Influences on Gastric Emptying of Carbohydrate versus Fat in the Rat
    David L. Trout, Emily S. Conway, John Putney · 1977 · Journal of Nutrition
  25. Glucagon and Diabetes
    Philip Raskin, Roger H. Unger · 1978 · Medical Clinics of North America
  26. Clinical Studies
    Andrew John Young · 2005 · Advances in pharmacology
  27. Dose-kinetics of pancreatic glucagon responses to arginine and glucose in subjects with normal and impaired pancreatic B cell function
    R Assan, Suad Efendić, R Luft, Erol Cerasi · 1981 · Diabetologia
  28. Influence of somatostatin on glucagon- and epinephrine-stimulated hepatic glucose output in the dog.
    Luigi Saccà, R. S. Sherwin, Philip Felig · 1979 · American Journal of Physiology-Endocrinology and Metabolism
  29. The Hypothalamic Regulatory Hormones and Their Clinical Applications
    Reginald Hall, Antonio Gómez-Pan · 1976 · Advances in clinical chemistry
  30. ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose
    Alessia Garufi, Daniela Trisciuoglio, Mara Cirone, Gabriella D’Orazi · 2016 · Cell Death and Disease
  31. Chemically and Hormonally Induced Diabetes Mellitus
    Albert Y. Chang, Arthur R. Diani · 1985 · Springer eBooks
  32. Remarkable potency of somatostatin as a glucagon suppressant
    Ellis Samols, James Harrison · 1976 · Metabolism
  33. Gastric Operations and Glucose Homeostasis
    Richard I. Breuer, Leon Zuckerman, T.W. Hauch, W. Green, Patrick T. O’Gara, A M Lawrence, P. P. Foà, Tatsuo Matsuyama · 1975 · Gastroenterology
  34. Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin.
    Lijun Chen, J. Philippe, R. Unger · 2011 · Endocrine Practice
  35. The Structural Refinement of Glucagon for Therapeutic Use.
    Joseph R. Chabenne, P. Mroz, J. Mayer, R. DiMarchi · 2019 · Journal of Medicinal Chemistry
  36. Effect of glucagon antibodies on plasma glucose, insulin and somatostatin in the fasting and fed rat
    K.S. Tan, D. Tsiolakis, Vincent Marks · 1985 · Diabetologia
  37. A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon‐derived peptide levels
    Masaki Kobayashi, Nobuhiro Maruyama, Yukako Yamamoto, Takeshi Togawa, Takanori Ida, Morikatsu Yoshida, Mikiya Miyazato, Masahisa Kitada, Yoshitaka Hayashi, Atsunori Kashiwagi et al. · 2023 · Journal of Diabetes Investigation
  38. Metabolic effects of pancreatectomy and hypophysectomy in the yellow American eel, Anguilla rostrata LeSueur
    August W. Epple, Thomas L. Lewis · 1977 · General and Comparative Endocrinology
  39. Insulin-Glucagon Interaction in Controlling Splanchnic Glucose Production in Norma Man
    James D. Bomboy, Stephen B. Lewis, BRUCE C. SINCLAIR-SMITH, WILLIAM W. LACY, JOHN E. LILJENQUIST · 1977 · The Journal of Clinical Endocrinology & Metabolism
  40. The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity
    Richard J. Mahler · 1981 · Acta Diabetologica
  41. LATE METASTASES IN OSTEOSARCOMA
    WataruW Sutow · 1976 · The Lancet
  42. DIABETES WITHOUT GLUCAGON
    John E. Gerich, J H Karam, Mara Lorenzi, Mark Donowitz, Philip Felig · 1976 · The Lancet
  43. The Metabolic Clearance of Endogenous Immunoreactive Glucagon and Exogenous Glucagon in Pancreatectomized and Sham-Operated Pigs*
    W. A. van Hoorn, A Vinik, R. Van Hoorn-Hickman · 1978 · Endocrinology
  44. Histidine Availability Alters Glucagon Gene Expression in Murine αTC6 Cells
    Gregory L. Paul, Aparna Waegner, H. Rex Gaskins, Neil F. Shay · 1998 · Journal of Nutrition
  45. Vagal stimulation and its role in eliciting gastrin but not glucagon release from the isolated perfused dog stomach.
    Pierre J. Lefèbvre, ALFRED S. LUYCKX, A H Brassinne · 1978 · Gut
  46. Radioautographic demonstration and localization of glucagon receptors in duck brain
    Anne Morales, Emmanuel Moyse, Hervé Barré · 1994 · Brain Research
  47. Glucagon and Its Relationship to Other Glucoregulatory Hormones in Exercise and Stress in Normal and Diabetic Subjects
    H.Lavina A. Lickley, Friedrich W. Kemmer, David H. Wasserman, M. Vranić · 1983 · Handbook of experimental pharmacology
  48. Hyperglycaemia and the risk of post-surgical adhesion
    Gordon A. Ferns, Seyed Mahdi Hassanian, Mohammad‐Hassan Arjmand · 2020 · Archives of Physiology and Biochemistry
  49. PLASMA-GLUCAGON AFTER PANCREATECTOMY
    Jerry P. Palmer · 1976 · The Lancet
  50. THE HYPOGLYCAEMIC ACTION OF SOMATOSTATIN IN THE ANAESTHETIZED DOG
    Christopher I. Blauth, Peter H. Sönksen, C. V. Tompkins, Stephen Robert Bloom · 1977 · Clinical Endocrinology
  51. Demonstration of gastric glucagon hypersecretion in insulin-deprived alloxan-diabetic dogs.
    Enrique Blázquez, L Muñoz-Barragán, Gloria S. Patton, RICHARD E. DOBBS, Roger H. Unger · 1977 · PubMed
  52. Somatostatin Leads to Glucagon's Renaissance
    Charles J. Goodner · 1975 · New England Journal of Medicine
  53. Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion
    P. Macdonald, P. Rorsman · 2011 · Diabetologia
  54. Expression of glucagon receptors in tetracycline‐inducible HEK293S GnT1− stable cell lines: An approach toward purification of receptor protein for structural studies
    Cecilia G. Unson · 2008 · Biopolymers
  55. Glucagon in Diabetes Mellitus
    Roger H. Unger, Lelio Orci · 1983 · Handbook of experimental pharmacology
  56. Glucagon structure-function relationships using isolated rat hepatocytes
    Victor J. Hruby, Nirankar S. Agarwal, Ann L. Griffen, Marvin D. Bregman, Charles A. Nugent, Klaus Brendel · 1981 · Biochimica et Biophysica Acta (BBA) - General Subjects
  57. The Role of Glucagon in Postprandial Hyperglycemia—The Jury’s Still Out
    Jenna Bollyky, Carla J. Greenbaum · 2007 · The Journal of Clinical Endocrinology & Metabolism
  58. Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis
    Tessa M. Cacciottolo, Katherine Lawler, Kevin M. Méndez-Acevedo, Edson Mendes de Oliveira, Adam M. Syanda, Elana Henning, Julia M. Keogh, Rebecca Bounds, Miriam Smith, Daniyal Ashraf et al. · 2025 · Diabetes
  59. Turbinafuranone A–C, new 2-furanone analogues from marine macroalga Turbinaria ornata as prospective anti-hyperglycemic agents attenuate tyrosine phosphatase-1B
    Shubhajit Dhara, Kajal Chakraborty · 2021 · Medicinal Chemistry Research
  60. EVIDENCE OF A ROLE FOR GLUCAGON IN REGULATING GLUCOSE AND β-HYDROXYBUTYRATE METABOLISM IN SHEEP
    Ronald P. Brockman, MARILYN R. JOHNSON · 1977 · Canadian Journal of Animal Science
  61. The development and regulation of the endocrine pancreas
    Harry J. Hirsch, Sherry Loo, Kenneth H. Gabbay · 1977 · The Journal of Pediatrics
  62. NEW PERSPECTIVES IN COMPARATIVE ISLET RESEARCH
    August W. Epple, Jack E. Brinn · 1976 · Elsevier eBooks
  63. Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States
    Isabel Valverde · 1977 · Springer eBooks
  64. Preparation and properties of glucagon analogs prepared by semi-synthesis from CNBr-glucagon
    David Wright, Victor J. Hruby, Martin Rodbell · 1980 · Biochimica et Biophysica Acta (BBA) - General Subjects
  65. Pathophysiology of Type 2 Diabetes
    Jothydev Kesavadev, Fatema Jawad, Asma Deeb, Ankia Coetzee, Mohammed Ansari, Dina Shrestha, Noel Pratheepan Somasundaram, Sanjay Kalra · 2023 · Springer eBooks
  66. Effects of Long-Acting Somatostatin Analogue (Sandostatin) on Manifest Diabetic Ketoacidosis
    Yong Seok Yun, Hyun‐Chul Lee, Chong Seok Park, Kyung Hee Chang, C. Cho, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Kap Bum Huh · 1999 · Journal of Diabetes and its Complications
  67. In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus
    Thomas H. Meek, Miles E. Matsen, Chelsea L. Faber, Colby L. Samstag, Vincent M. Damian, Nguyễn Thị Hồng, Jarrad M. Scarlett, Jonathan N. Flak, Martin Grosvenor Myers, Gregory J. Morton · 2018 · Endocrinology
  68. The Role of Salt Bridge Formation in Glucagon: An Experimental and Theoretical Study of Glucagon Analogs and Peptide Fragments of Glucagon
    Anne‐Marie Sapse, Robert Rothchild, Duli C. Jain, Cecilia G. Unson · 2002 · Molecular Medicine
  69. Extrapancreatic Glucagon and Its Regulation
    Pierre J. Lefèbvre, ALFRED S. LUYCKX · 1983 · Handbook of experimental pharmacology
  70. Response of extrapancreatic glucagon to arginine in dogs.
    Akira Ohneda, Takashi Kobayashi, Jiro Nihei, MASANORI UMEZU, TAKEAKI SAKAI, Kyo Sanoyama · 1979 · The Tohoku Journal of Experimental Medicine
  71. Rates of Removal of Exogenous and Endogenous Glucagon From the Plasma of Sheep in Vivo
    Ronald P. Brockman · 1980 · Australian Journal of Biological Sciences
  72. Gluconeogenesis in Infancy and Childhood: I. A Method for the Study of the in vivo Gluconeogenesis from Alanine and Glycerol
    Jostein Vidnes · 1976 · Scandinavian Journal of Clinical and Laboratory Investigation
  73. Glucagon and somatostatin
    Roger H. Unger · 1978 · Disease-a-Month
  74. Glucagon suppression improves glucoregulation in moderate but not chronic severe diabetes
    H.Lavina A. Lickley, Friedrich W. Kemmer, Katsumi Doi, M. Vranić · 1983 · American Journal of Physiology-Endocrinology and Metabolism
  75. The milieu interieur and the islets of Langerhans
    Roger H. Unger · 1981 · Diabetologia
  76. Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes
    Yoshihiro Banno, Shigekazu Sasaki, Makoto Kamata, Jun Kunitomo, Yasufumi Miyamoto, Hidenori Abe, Naohiro Taya, Satoru Oi, Masanori Watanabe, Tomoko Urushibara et al. · 2017 · Bioorganic & Medicinal Chemistry
  77. Glucagon: Secretion and Actions
    Mark A. Sperling · 1979 · Advances in experimental medicine and biology
  78. GLUCAGON AND DIABETES
    Donald A. Perry‐Keene, FRANK P. ALFORD, Donald J. Chisholm, David M. Findlay, Richard G. Larkins, F. I. R. Martin · 1977 · Clinical Endocrinology
  79. Glucagon and Blood Glucose: Insights from Artificial Pancreas Studies
    Philip Felig, ROBERT S. SHERWIN · 1980 · Annals of Internal Medicine
  80. Somatostatin and Diabetes Mellitus: The Role of Glucagon in Diabetic Hyperglycemia and Glucose Intolerance
    John Wahren · 1976 · Scandinavian Journal of Clinical and Laboratory Investigation
  81. Inhibition by somatostatin of carbamylcholine-induced gastrin and glucagon release from the isolated perfused canine stomach.
    Pierre J. Lefèbvre, ALFRED S. LUYCKX, A H Brassinne · 1981 · Gut
  82. Type 1 diabetes: key drug targets and how they could influence future therapeutics
    Yoon Kook Kim, Kashif M. Munir, Stephen N. Davis · 2023 · Expert Opinion on Therapeutic Targets
  83. Glucagon:
    Victor J. Hruby · 1997 · Principles of medical biology
  84. Glucagon secretion in late pregnancy and the puerperium
    Hélène Leblanc, J.R. Anderson, Samuel S.C. Yen · 1976 · American Journal of Obstetrics and Gynecology
  85. Ketoacidosis and Hyperosmolar Coma
    Daniel W. Foster, Victoria Esser · 2010 · Elsevier eBooks
  86. Immunoreactive Glucagon in the Salivary Glands of Man and Animal
    Sally Hojvat, Lidia Kirsteins, J. Kisla, V. Paloyan, A. M. Lawrence · 1977 · Springer eBooks
  87. Glucagon and Glucagon‐like Peptide Production and Degradation
    Timothy J. Kieffer, Mehboob Ali Hussain, Joel Francis Habener · 2001 · Comprehensive physiology
  88. Pathogenesis, diagnosis and treatment of diabetic ketoacidosis
    Maurice D. Kogut · 1976 · Current Problems in Pediatrics
  89. The Pharmacology and Potential Clinical Applications of Somatostatin and its Analogues
    John E. Gerich · 1980 · Springer eBooks
  90. An ab initio study of non-peptide glucagon receptor antagonists
    Anne‐Marie Sapse, Shannon Lawton, Robert Rothchild, Cecilia G. Unson · 2003 · Journal of Molecular Structure THEOCHEM
  91. Tolbutamide: Stimulator and Suppressor of Glucagon Secretion
    Ellis Samols, J. Harrison · 1977 · Springer eBooks
  92. Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment
    Savita Dhanvantari, E. Danielle Dean · 2025 · Endocrinology
  93. Pathophysiology of Type 2 Diabetes
    Jothydev Kesavadev, Fatema Jawad, Asma Deeb, Ankia Coetzee, Mohammed Ansari, Dina Shrestha, Noel Pratheepan Somasundaram, Sanjay Kalra · 2019 · Springer eBooks
  94. Pancreastatin inhibitor PSTi8 ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production
    Richa Garg, Roshan A. Katekar, Shahid Parwez, Arun Kumar Agarwal, Sudhanshu Sahu, Shailesh D. Dadge, Saurabh Verma, Umesh Kumar Goand, Mohammad Imran Siddiqi, Jiaur Rahaman Gayen · 2023 · European Journal of Pharmacology
  95. Glucagon and the Glucagon Receptor: Merrifield Years at the Interface of Chemistry and Biology
    Cecilia G. Unson · 2007 · International Journal of Peptide Research and Therapeutics
  96. Change of glucagon reacting to 30 K antibody in totally depancreatized dogs
    Takaaki Sudo, Katsuhiko Konishi, A Nakase, Takashi Suzuki, Ichiro Nishimura, Takayoshi Tobe · 1978 · Gastroenterologia Japonica
  97. Hormones
    Julien L. Van Lancker · 1976 · Springer eBooks
  98. Revisiting the Pharmacological Value of Glucagon: An Editorial for the Special Issue “The Biology and Pharmacology of Glucagon”
    Timo D. Müller, Kirk M. Habegger · 2020 · International Journal of Molecular Sciences
  99. Somatostatin-Induced Changes in the Hemostasis of Rats
    Michael William Long, Piero Micossi, Antonio Ettore Pontiroli, Joseph C. Dunbar, Piero P. Foà, Raymond L. Henry · 1979 · Thrombosis and Haemostasis
  100. Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes
    Rachel J. Perry · 2017 · Postdoc Journal