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Genetic Basis of Natural Variation in D. melanogaster Antibacterial Immunity
Abstract
Many genes involved in Drosophila melanogaster innate immune processes have been identified, but whether naturally occurring polymorphism in these genes leads to variation in immune competence among wild flies has not been tested. We report here substantial variability among wild-derived D. melanogaster in the ability to suppress infection by a Gram-negative entomopathogen, Serratia marcescens . Variability in immune competence was significantly associated with nucleotide polymorphism in 16 innate immunity genes, corresponding primarily to pathogen recognition and intracellular signaling loci, and substantial epistasis was detected between intracellular signaling and antimicrobial peptide genes. Variation in these genes, therefore, seems to drive variability in immunocompetence among wild Drosophila .
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Cited by
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Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135
Schneider, D. S., & Ayres, J. S. (2008) · Nature Reviews Immunology · doi:10.1038/nri2432 · Cited by 783
Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
Waterhouse, R. M., Kriventseva, E. V., Meister, S., Xi, Z., Alvarez, K. S., Bartholomay, L. C., Barillas-Mury, C., Bian, G., Blandin, S., Christensen, B. M., et al. (2007) · Science · doi:10.1126/science.1139862 · Cited by 665
Reconstructing immune phylogeny: new perspectives
Litman, G. W., Cannon, J. P., & Dishaw, L. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1712 · Cited by 353
Invertebrate immunity and the limits of mechanistic immunology
Little, T. J., Hultmark, D., & Read, A. F. (2005) · Nature Immunology · doi:10.1038/ni1219 · Cited by 296
Metadata
- Authors
- Lazzaro, B. P., Sceurman, B. K., & Clark, A. G.
- Venue
- Science
- Published
- 2004-03-19
- Volume
- 303
- Issue
- 5665
- Pages
- 1873-1876
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983151212
- Cited by
- 236
- References
- 0
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lazzaro, B. P., Sceurman, B. K., & Clark, A. G. (2004). Genetic Basis of Natural Variation in D. melanogaster Antibacterial Immunity. Science. https://doi.org/10.1126/science.1092447
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