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Actin Polymerization-Driven Molecular Movement of mDia1 in Living Cells
Open accessAbstract
mDia1, a Rho effector, belongs to the Formin family of proteins, which shares the conserved tandem FH1-FH2 unit structure. Formins including mDia1 accelerate actin nucleation while interacting with actin filament fast-growing ends. Here our single-molecule imaging revealed fast directional movement of mDia1 FH1-FH2 for tens of microns in living cells. The movement of mDia1 FH1-FH2 was blocked by actin-perturbing drugs, and the speed of mDia1 FH1-FH2 movement appeared to correlate with actin elongation rates. In vitro, mDia1 FH1-FH2 associated persistently with the growing actin barbed end. mDia1 probably moves processively along the growing end of actin filaments in cells, and Formins may be a molecular motility machinery that is independent from motor proteins.
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Cited by
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa-Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,457
Stress fibers are generated by two distinct actin assembly mechanisms in motile cells
Hotulainen, P., & Lappalainen, P. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511093 · Cited by 934
Actin and Actin-Binding Proteins
Pollard, T. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018226 · Cited by 912
Maness, P. F., & Schachner, M. (2007) · Nature Neuroscience · doi:10.1038/nn1827 · Cited by 847
Two Distinct Actin Networks Drive the Protrusion of Migrating Cells
Ponti, A., Machacek, M., Gupton, S. L., Waterman-Storer, C. M., & Danuser, G. (2004) · Science · doi:10.1126/science.1100533 · Cited by 819
Metadata
- Authors
- Higashida, C., Miyoshi, T., Fujita, A., Oceguera-Yanez, F., Monypenny, J., Andou, Y., Narumiya, S., & Watanabe, N.
- Venue
- Science
- Published
- 2004-03-26
- Volume
- 303
- Issue
- 5666
- Pages
- 2007-2010
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1973870846
- Cited by
- 312
- References
- 0
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Higashida, C., Miyoshi, T., Fujita, A., Oceguera-Yanez, F., Monypenny, J., Andou, Y., Narumiya, S., & Watanabe, N. (2004). Actin Polymerization-Driven Molecular Movement of mDia1 in Living Cells. Science. https://doi.org/10.1126/science.1093923
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