The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells
Abstract
Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.
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Cites
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Self-citationTbr1 regulates differentiation of the preplate and layer 6
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Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
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LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal
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Self-citationDifferentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
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Cited by
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3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs
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The Pathobiology of Vascular Dementia
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“Endothelial cells have the potential to stimulate the proliferation of neuronal precursors and to stir their differentiation toward the neuronal lineage (Shen et al., 2004).”
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
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Metadata
- Authors
- Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K., & Temple, S.
- Venue
- Science
- Published
- 2004-05-28
- Volume
- 304
- Issue
- 5675
- Pages
- 1338-1340
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965681567
- Cited by
- 1,542
- References
- 17
- FWCI
- 22.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K., & Temple, S. (2004). Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells. Science. https://doi.org/10.1126/science.1095505
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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