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Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt + Cells
Abstract
Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to differentiate from local precursors rather than from thymocytes. We show here that IELs expressingthe αβ T cell receptor are derived from precursors that express RORγt, an orphan nuclear hormone receptor detected only in immature CD4 + CD8 + thymocytes, fetal lymphoid tissue–inducer (LTi) cells, and LTi-like cells in cryptopatches within the adult intestinal lamina propria. Using cell fate mapping, we found that all intestinal αβ T cells are progeny of CD4 + CD8 + thymocytes, indicatingthat the adult intestine is not a significant site for αβ T cell development. Our results suggest that intestinal RORγt + cells are local organizers of mucosal lymphoid tissue.
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Yang, X. W., Model, P., & Heintz, N. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-859 · Cited by 544
Cited by
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Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
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Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
Self-citationLymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107
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Metadata
- Authors
- Eberl, G., & Littman, D. R.
- Venue
- Science
- Published
- 2004-07-09
- Volume
- 305
- Issue
- 5681
- Pages
- 248-251
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067850515
- Cited by
- 513
- References
- 1
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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