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The Binding Mode of Epothilone A on α,ß-Tubulin by Electron Crystallography
Abstract
The structure of epothilone A, bound to α,β-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom resolution and nuclear magnetic resonance–based conformational analysis. The complex explains both the broad-based epothilone structure-activity relationship and the known mutational resistance profile. Comparison with Taxol shows that the longstanding expectation of a common pharmacophore is not met, because each ligand exploits the tubulin-binding pocket in a unique and independent manner.
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Citations
Cited by
Microtubules and resistance to tubulin-binding agents
Kavallaris, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2803 · Cited by 1,120
Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014) · Cell · doi:10.1016/j.cell.2014.03.053 · Cited by 696
Targeting Microtubules by Natural Agents for Cancer Therapy
Mukhtar, E., Adhami, V. M., & Mukhtar, H. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0791 · Cited by 565
Perez, E. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0366 · Cited by 521
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
Prota, A. E., Bargsten, K., Zurwerra, D., Field, J. J., Díaz, J. F., Altmann, K.-H., & Steinmetz, M. O. (2013) · Science · doi:10.1126/science.1230582 · Cited by 489
Metadata
- Authors
- Nettles, J. H., Li, H., Cornett, B., Krahn, J. M., Snyder, J. P., & Downing, K. H.
- Venue
- Science
- Published
- 2004-08-06
- Volume
- 305
- Issue
- 5685
- Pages
- 866-869
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070116427
- Cited by
- 421
- References
- 0
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nettles, J. H., Li, H., Cornett, B., Krahn, J. M., Snyder, J. P., & Downing, K. H. (2004). The Binding Mode of Epothilone A on α,ß-Tubulin by Electron Crystallography. Science. https://doi.org/10.1126/science.1099190
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