The DOI matches its Crossref record.
A Plant Vacuolar Protease, VPE, Mediates Virus-Induced Hypersensitive Cell Death
Abstract
Programmed cell death (PCD) in animals depends on caspase protease activity. Plants also exhibit PCD, for example as a response to pathogens, although a plant caspase remains elusive. Here we show that vacuolar processing enzyme (VPE) is a protease essential for a virus-induced hypersensitive response that involves PCD. VPE deficiency prevented virus-induced hypersensitive cell death in tobacco plants. VPE is structurally unrelated to caspases, although VPE has a caspase-1 activity. Thus, plants have evolved a regulated cellular suicide strategy that, unlike PCD of animals, is mediated by VPE and the cellular vacuole.
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Cited by
Programmed cell death in the plant immune system
Coll, N. S., Epple, P., & Dangl, J. L. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.37 · Cited by 915
Morphological classification of plant cell deaths
van Doorn, W. G., Beers, E. P., Dangl, J. L., Franklin-Tong, V. E., Gallois, P., Hara-Nishimura, I., Jones, A. M., Kawai-Yamada, M., Lam, E., Mundy, J., et al. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.36 · Cited by 584
Self-citationChong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536
Quattrocchio, F., Verweij, W., Kroon, A., Spelt, C., Mol, J., & Koes, R. (2006) · The Plant Cell · doi:10.1105/tpc.105.034041 · Cited by 401
Autophagic Components Contribute to Hypersensitive Cell Death in Arabidopsis
Hofius, D., Schultz-Larsen, T., Joensen, J., Tsitsigiannis, D. I., Petersen, N. H. T., Mattsson, O., Jørgensen, L. B., Jones, J. D. G., Mundy, J., & Petersen, M. (2009) · Cell · doi:10.1016/j.cell.2009.02.036 · Cited by 375
Metadata
- Authors
- Hatsugai, N., Kuroyanagi, M., Yamada, K., Meshi, T., Tsuda, S., Kondo, M., Nishimura, M., & Hara-Nishimura, I.
- Venue
- Science
- Published
- 2004-08-06
- Volume
- 305
- Issue
- 5685
- Pages
- 855-858
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024077782
- Cited by
- 621
- References
- 0
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hatsugai, N., Kuroyanagi, M., Yamada, K., Meshi, T., Tsuda, S., Kondo, M., Nishimura, M., & Hara-Nishimura, I. (2004). A Plant Vacuolar Protease, VPE, Mediates Virus-Induced Hypersensitive Cell Death. Science. https://doi.org/10.1126/science.1099859
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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