The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain
Abstract
To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of inhibitors, termed ubistatins, blocked cell cycle progression by inhibiting cyclin B proteolysis and inhibited degradation of ubiquitinated Sic1 by purified proteasomes. Ubistatins blocked the binding of ubiquitinated substrates to the proteasome by targeting the ubiquitin-ubiquitin interface of Lys 48 -linked chains. The same interface is recognized by ubiquitin-chain receptors of the proteasome, indicating that ubistatins act by disrupting a critical protein-protein interaction in the ubiquitin-proteasome system.
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Citations
Cites
Control of β-Catenin Stability
Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80446-3 · Cited by 335
Cited by
Polyubiquitin chains: polymeric protein signals
Pickart, C. M., & Fushman, D. (2004) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.09.009 · Cited by 1,049
Self-citationDrug discovery in the ubiquitin–proteasome system
Nalepa, G., Rolfe, M., & Harper, J. W. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2056 · Cited by 608
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C
Sackton, K. L., Dimova, N., Zeng, X., Tian, W., Zhang, M., Sackton, T. B., Meaders, J., Pfaff, K. L., Sigoillot, F., Yu, H., et al. (2014) · Nature · doi:10.1038/nature13660 · Cited by 257
Self-citationWeighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
Kirkpatrick, D. S., Denison, C., & Gygi, S. P. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-750 · Cited by 209
De Caterina, R., & Massaro, M. (2005) · Journal of Membrane Biology · doi:10.1007/s00232-005-0783-2 · Cited by 130
Metadata
- Authors
- Verma, R., Peters, N. R., D'Onofrio, M., Tochtrop, G. P., Sakamoto, K. M., Varadan, R., Zhang, M., Coffino, P., Fushman, D., Deshaies, R. J., & King, R. W.
- Venue
- Science
- Published
- 2004-10
- Volume
- 306
- Issue
- 5693
- Pages
- 117-120
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2143156516
- Cited by
- 193
- References
- 1
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Verma, R., Peters, N. R., D'Onofrio, M., Tochtrop, G. P., Sakamoto, K. M., Varadan, R., Zhang, M., Coffino, P., Fushman, D., Deshaies, R. J., & King, R. W. (2004). Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain. Science. https://doi.org/10.1126/science.1100946
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
