The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus
Abstract
The cascade of events that leads to vaccinia-induced actin polymerization requires Src-dependent tyrosine phosphorylation of the viral membrane protein A36R. We found that a localized outside-in signaling cascade induced by the viral membrane protein B5R is required to potently activate Src and induce A36R phosphorylation at the plasma membrane. In addition, Src-mediated phosphorylation of A36R regulated the ability of virus particles to recruit and release conventional kinesin. Thus, Src activity regulates the transition between cytoplasmic microtubule transport and actin-based motility at the plasma membrane.
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Citations
Cites
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982
Cited by
McFadden, G. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1099 · Cited by 523
Microtubules in Cell Migration
Etienne-Manneville, S. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155711 · Cited by 508
A Superhighway to Virus Infection
Greber, U. F., & Way, M. (2006) · Cell · doi:10.1016/j.cell.2006.02.018 · Cited by 383
Self-citationActin-based motility of intracellular pathogens
Gouin, E., Welch, M. D., & Cossart, P. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.12.013 · Cited by 358
Poxviruses and the evolution of host range and virulence
Haller, S. L., Peng, C., McFadden, G., & Rothenburg, S. (2014) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2013.10.014 · Cited by 321
Metadata
- Authors
- Newsome, T. P., Scaplehorn, N., & Way, M.
- Venue
- Science
- Published
- 2004-10
- Volume
- 306
- Issue
- 5693
- Pages
- 124-129
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989569988
- Cited by
- 161
- References
- 1
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Newsome, T. P., Scaplehorn, N., & Way, M. (2004). Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus. Science. https://doi.org/10.1126/science.1101509
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
