The DOI matches its Crossref record.
Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells
Open accessAbstract
We report that Id knockout mouse embryos display multiple cardiac defects, but mid-gestation lethality is rescued by the injection of 15 wild-type embryonic stem (ES) cells into mutant blastocysts. Myocardial markers altered in Id mutant cells are restored to normal throughout the chimeric myocardium. Intraperitoneal injection of ES cells into female mice before conception also partially rescues the cardiac phenotype with no incorporation of ES cells. Insulin-like growth factor 1, a long-range secreted factor, in combination with WNT5a, a locally secreted factor, likely account for complete reversion of the cardiac phenotype. Thus, ES cells have the potential to reverse congenital defects through Id-dependent local and long-range effects in a mammalian embryo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,314
von Gise, A., Zhou, B., Honor, L. B., Ma, Q., Petryk, A., & Pu, W. T. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.05.668 · Cited by 252
Stromal cell-derived factor-1α is cardioprotective after myocardial infarction
Saxena, A., Fish, J. E., White, M. D., Yu, S., Smyth, J. W. P., Shaw, R. M., DiMaio, J. M., & Srivastava, D. (2008) · Circulation · doi:10.1161/circulationaha.107.694992 · Cited by 237
Metadata
- Authors
- Fraidenraich, D., Stillwell, E., Romero, E., Wilkes, D., Manova, K., Basson, C. T., & Benezra, R.
- Venue
- Science
- Published
- 2004-10-08
- Volume
- 306
- Issue
- 5694
- Pages
- 247-252
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053929334
- Cited by
- 215
- References
- 0
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells. https://app.cochat.ai/papers/10.1126/science.1102612
- The paper
- Fraidenraich, D., Stillwell, E., Romero, E., Wilkes, D., Manova, K., Basson, C. T., & Benezra, R. (2004). Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells. Science. https://doi.org/10.1126/science.1102612
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
