The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles
Open accessAbstract
The translation of nucleic acid libraries into corresponding synthetic compounds would enable selection and amplification principles to be applied to man-made molecules. We used multistep DNA-templated organic synthesis to translate libraries of DNA sequences, each containing three “codons,” into libraries of sequence-programmed synthetic small-molecule macrocycles. The resulting DNA-macrocycle conjugates were subjected to in vitro selections for protein affinity. The identity of a single macrocycle possessing known target protein affinity was inferred through the sequence of the amplified DNA template surviving the selection. This work represents the translation, selection, and amplification of libraries of nucleic acids encoding synthetic small molecules rather than biological macromolecules.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Maryanoff, B. E., & Reitz, A. B. (1989) · Chemical Reviews · doi:10.1021/cr00094a007 · Cited by 2,605
Organic reactions in aqueous media
(1998) · Choice Reviews Online · doi:10.5860/choice.35-3311 · Cited by 1,260
In Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,206
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Lamarre, D., Anderson, P. C., Bailey, M., Beaulieu, P., Bolger, G., Bonneau, P., Bös, M., Cameron, D. R., Cartier, M., Cordingley, M. G., et al. (2003) · Nature · doi:10.1038/nature02099 · Cited by 917
Carbonic Anhydrase: New Insights for an Ancient Enzyme
Tripp, B. C., Smith, K., & Ferry, J. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100045200 · Cited by 565
Directed Evolution of Nucleic Acid Enzymes
Joyce, G. F. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073717 · Cited by 515
The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules
Gartner, Z. J., & Liu, D. R. (2001) · Journal of the American Chemical Society · doi:10.1021/ja015873n · Cited by 282
Self-citationWoodward, R. B., Logusch, E., Nambiar, K. P., Sakan, K., Ward, D. E., Au-Yeung, B. W., Balaram, P., Browne, L. J., Card, P. J., & Chen, C. H. (1981) · Journal of the American Chemical Society · doi:10.1021/ja00401a049 · Cited by 257
Investigating and Engineering Enzymes by Genetic Selection
Taylor, S. V., Kast, P., & Hilvert, D. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010917)40:18<3310::aid-anie3310>3.0.co;2-p · Cited by 205
Expanding the Reaction Scope of DNA-Templated Synthesis
Gartner, Z. J., Kanan, M. W., & Liu, D. R. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020517)41:10<1796::aid-anie1796>3.0.co;2-z · Cited by 192
Self-citation
Cited by
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
The exploration of macrocycles for drug discovery — an underexploited structural class
Driggers, E. M., Hale, S. P., Lee, J., & Terrett, N. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2590 · Cited by 1,370
Marsault, E., & Peterson, M. L. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm1012374 · Cited by 843
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Heinis, C., Rutherford, T., Freund, S., & Winter, G. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.184 · Cited by 743
DNA as a universal substrate for chemical kinetics
Soloveichik, D., Seelig, G., & Winfree, E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909380107 · Cited by 693
Metadata
- Authors
- Gartner, Z. J., Tse, B. N., Grubina, R., Doyon, J. B., Snyder, T. M., & Liu, D. R.
- Venue
- Science
- Published
- 2004-09-10
- Volume
- 305
- Issue
- 5690
- Pages
- 1601-1605
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2096216335
- Cited by
- 503
- References
- 17
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. https://app.cochat.ai/papers/10.1126/science.1102629
- The paper
- Gartner, Z. J., Tse, B. N., Grubina, R., Doyon, J. B., Snyder, T. M., & Liu, D. R. (2004). DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. Science. https://doi.org/10.1126/science.1102629
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
