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The G s -Linked Receptor GPR3 Maintains Meiotic Arrest in Mammalian Oocytes
Abstract
Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic cells. Here we show that the orphan G s -linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes. Thus, the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis.
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Citations
Cited by
Genetics of primary ovarian insufficiency: new developments and opportunities
Qin, Y., Jiao, X., Simpson, J. L., & Chen, Z.-J. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv036 · Cited by 554
Calcium at Fertilization and in Early Development
Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
Coticchio, G., Dal Canto, M., Mignini Renzini, M., Guglielmo, M. C., Brambillasca, F., Turchi, D., Novara, P. V., & Fadini, R. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv011 · Cited by 502
Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism
Meyer zu Heringdorf, D., & Jakobs, K. H. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.026 · Cited by 388
Hsieh, M., Lee, D., Panigone, S., Horner, K., Chen, R., Theologis, A., Lee, D. C., Threadgill, D. W., & Conti, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01919-06 · Cited by 329
Metadata
- Authors
- Mehlmann, L. M., Saeki, Y., Tanaka, S., Brennan, T. J., Evsikov, A. V., Pendola, F. L., Knowles, B. B., Eppig, J. J., & Jaffe, L. A.
- Venue
- Science
- Published
- 2004-12-10
- Volume
- 306
- Issue
- 5703
- Pages
- 1947-1950
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2163174772
- Cited by
- 337
- References
- 0
- FWCI
- 19.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mehlmann, L. M., Saeki, Y., Tanaka, S., Brennan, T. J., Evsikov, A. V., Pendola, F. L., Knowles, B. B., Eppig, J. J., & Jaffe, L. A. (2004). The G s -Linked Receptor GPR3 Maintains Meiotic Arrest in Mammalian Oocytes. Science. https://doi.org/10.1126/science.1103974
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