The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Glycolipids as Receptors for Bacillus thuringiensis Crystal Toxin
Abstract
The development of pest resistance threatens the effectiveness of Bacillus thuringiensis (Bt) toxins used in transgenic and organic farming. Here, we demonstrate that (i) the major mechanism for Bt toxin resistance in Caenorhabditis elegans entails a loss of glycolipid carbohydrates; (ii) Bt toxin directly and specifically binds glycolipids; and (iii) this binding is carbohydrate-dependent and relevant for toxin action in vivo. These carbohydrates contain the arthroseries core conserved in insects and nematodes but lacking in vertebrates. We present evidence that insect glycolipids are also receptors for Bt toxin.
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Citations
Cites
Sustainability of Transgenic Insecticidal Cultivars: Integrating Pest Genetics and Ecology
Gould, F. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.701 · Cited by 1,392
Yield effects of genetically modified crops in developing countries
Qaim, M., & Zilberman, D. (2003) · Science · doi:10.1126/science.1080609 · Cited by 757
Cited by
Role of Receptors in Bacillus thuringiensis Crystal Toxin Activity
Pigott, C. R., & Ellar, D. J. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-06 · Cited by 688
The Natural Biotic Environment of Caenorhabditis elegans
Schulenburg, H., & Félix, M.-A. (2017) · Genetics · doi:10.1534/genetics.116.195511 · Cited by 437
McGhee, J. (2007) · WormBook · doi:10.1895/wormbook.1.133.1 · Cited by 324
Plant lipids: Key players of plasma membrane organization and function
Mamode Cassim, A., Gouguet, P., Gronnier, J., Laurent, N., Germain, V., Grison, M., Boutté, Y., Gerbeau-Pissot, P., Simon-Plas, F., & Mongrand, S. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.11.002 · Cited by 266
Bacterial pore-forming toxins: The (w)hole story?
Gonzalez, M. R., Bischofberger, M., Pernot, L., van der Goot, F. G., & Frêche, B. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7434-y · Cited by 262
Metadata
- Authors
- Griffitts, J. S., Haslam, S. M., Yang, T., Garczynski, S. F., Mulloy, B., Morris, H., Cremer, P. S., Dell, A., Adang, M. J., & Aroian, R. V.
- Venue
- Science
- Published
- 2005-02-11
- Volume
- 307
- Issue
- 5711
- Pages
- 922-925
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999972142
- Cited by
- 352
- References
- 2
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Griffitts, J. S., Haslam, S. M., Yang, T., Garczynski, S. F., Mulloy, B., Morris, H., Cremer, P. S., Dell, A., Adang, M. J., & Aroian, R. V. (2005). Glycolipids as Receptors for Bacillus thuringiensis Crystal Toxin. Science. https://doi.org/10.1126/science.1104444
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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