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An Active Role for tRNA in Decoding Beyond Codon:Anticodon Pairing
Abstract
During transfer RNA (tRNA) selection, a cognate codon:anticodon interaction triggers a series of events that ultimately results in the acceptance of that tRNA into the ribosome for peptide-bond formation. High-fidelity discrimination between the cognate tRNA and near- and noncognate ones depends both on their differential dissociation rates from the ribosome and on specific acceleration of forward rate constants by cognate species. Here we show that a mutant tRNA Trp carrying a single substitution in its D-arm achieves elevated levels of miscoding by accelerating these forward rate constants independent of codon:anticodon pairing in the decoding center. These data provide evidence for a direct role for tRNA in signaling its own acceptance during decoding and support its fundamental role during the evolution of protein synthesis.
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Cites
Crystal structure of the ribosome at 5.5 Å resolution
Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H. D., & Noller, H. F. (2001) · Science · doi:10.1126/science.1060089 · Cited by 1,944
Cited by
What recent ribosome structures have revealed about the mechanism of translation
Schmeing, T. M., & Ramakrishnan, V. (2009) · Nature · doi:10.1038/nature08403 · Cited by 699
The bacterial ribosome as a target for antibiotics
Poehlsgaard, J., & Douthwaite, S. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1265 · Cited by 607
tRNA’s Wobble Decoding of the Genome: 40 Years of Modification
Agris, P. F., Vendeix, F. A. P., & Graham, W. D. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.046 · Cited by 543
Fidelity at the Molecular Level: Lessons from Protein Synthesis
Zaher, H. S., & Green, R. (2009) · Cell · doi:10.1016/j.cell.2009.01.036 · Cited by 386
Self-citationAn integrated, structure- and energy-based view of the genetic code
Grosjean, H., & Westhof, E. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw608 · Cited by 278
Metadata
- Authors
- Cochella, L., & Green, R.
- Venue
- Science
- Published
- 2005-05-20
- Volume
- 308
- Issue
- 5725
- Pages
- 1178-1180
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017411951
- Cited by
- 213
- References
- 1
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
