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Principles of Selective Ion Transport in Channels and Pumps

Gouaux, Eric, MacKinnon, Roderick·2005·Science

Abstract

The transport of ions across the membranes of cells and organelles is a prerequisite for many of life's processes. Transport often involves very precise selectivity for specific ions. Recently, atomic-resolution structures have been determined for channels or pumps that are selective for sodium, potassium, calcium, and chloride: four of the most abundant ions in biology. From these structures we can begin to understand the principles of selective ion transport in terms of the architecture and detailed chemistry of the ion conduction pathways.

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Metadata

Authors
Gouaux, E., & MacKinnon, R.
Venue
Science
Published
2005-12-02
Volume
310
Issue
5753
Pages
1461-1465
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1999838269
Cited by
1,059
References
1
FWCI
12.45
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Principles of Selective Ion Transport in Channels and Pumps. https://app.cochat.ai/papers/10.1126/science.1113666
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Gouaux, E., & MacKinnon, R. (2005). Principles of Selective Ion Transport in Channels and Pumps. Science. https://doi.org/10.1126/science.1113666

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.