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C-H Bond Functionalization in Complex Organic Synthesis
Abstract
Direct and selective replacement of carbon-hydrogen bonds with new bonds (such as C–C, C–O, and C–N) represents an important and long-standing goal in chemistry. These transformations have broad potential in synthesis because C–H bonds are ubiquitous in organic substances. At the same time, achieving selectivity among many different C–H bonds remains a challenge. Here, we focus on the functionalization of C–H bonds in complex organic substrates catalyzed by transition metal catalysts. We outline the key concepts and approaches aimed at achieving selectivity in complex settings and discuss the impact these reactions have on synthetic planning and strategy in organic synthesis.
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Cited by
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
Arockiam, P. B., Bruneau, C., & Dixneuf, P. H. (2012) · Chemical Reviews · doi:10.1021/cr300153j · Cited by 2,743
Wang, C., Daimon, H., Onodera, T., Koda, T., & Sun, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800073 · Cited by 849
Noble, A., McCarver, S. J., & MacMillan, D. W. C. (2015) · Journal of the American Chemical Society · doi:10.1021/ja511913h · Cited by 448
Palladium-catalysed transannular C–H functionalization of alicyclic amines
Topczewski, J. J., Cabrera, P. J., Saper, N. I., & Sanford, M. S. (2016) · Nature · doi:10.1038/nature16957 · Cited by 328
Metadata
- Authors
- Godula, K., & Sames, D.
- Venue
- Science
- Published
- 2006-04-07
- Volume
- 312
- Issue
- 5770
- Pages
- 67-72
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2164631251
- Cited by
- 2,161
- References
- 0
- FWCI
- 61.62
- Type
- journal article
- Language
- en
- Open access
- closed
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