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fgf20 Is Essential for Initiating Zebrafish Fin Regeneration
Abstract
Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema ( dob ) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb . Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.
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Cited by
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Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
The zebrafish as a model for complex tissue regeneration
Gemberling, M., Bailey, T. J., Hyde, D. R., & Poss, K. D. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.07.003 · Cited by 566
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
Stoick-Cooper, C. L., Weidinger, G., Riehle, K. J., Hubbert, C., Major, M. B., Fausto, N., & Moon, R. T. (2007) · Development · doi:10.1242/dev.001123 · Cited by 532
Comparative Aspects of Animal Regeneration
Brockes, J. P., & Kumar, A. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175336 · Cited by 490
Bridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
Metadata
- Authors
- Whitehead, G. G., Makino, S., Lien, C.-L., & Keating, M. T.
- Venue
- Science
- Published
- 2005-12-23
- Volume
- 310
- Issue
- 5756
- Pages
- 1957-1960
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985207433
- Cited by
- 294
- References
- 0
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Whitehead, G. G., Makino, S., Lien, C.-L., & Keating, M. T. (2005). fgf20 Is Essential for Initiating Zebrafish Fin Regeneration. Science. https://doi.org/10.1126/science.1117637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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