The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
ATP Signaling Is Crucial for Communication from Taste Buds to Gustatory Nerves
Abstract
Taste receptor cells detect chemicals in the oral cavity and transmit this information to taste nerves, but the neurotransmitter(s) have not been identified. We report that adenosine 5′-triphosphate (ATP) is the key neurotransmitter in this system. Genetic elimination of ionotropic purinergic receptors (P2X 2 and P2X 3 ) eliminates taste responses in the taste nerves, although the nerves remain responsive to touch, temperature, and menthol. Similarly, P2X-knockout mice show greatly reduced behavioral responses to sweeteners, glutamate, and bitter substances. Finally, stimulation of taste buds in vitro evokes release of ATP. Thus, ATP fulfils the criteria for a neurotransmitter linking taste buds to the nervous system.
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Citations
Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Cited by
An Evolutionary Perspective on Food and Human Taste
Breslin, P. A. S. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.010 · Cited by 508
Liman, E. R., Zhang, Y. V., & Montell, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.022 · Cited by 473
The neural mechanisms of gustation: A distributed processing code
Simon, S. A., de Araujo, I. E., Gutierrez, R., & Nicolelis, M. A. L. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2006 · Cited by 305
Glucagon‐like peptide‐1 is specifically involved in sweet taste transmission
Takai, S., Yasumatsu, K., Inoue, M., Iwata, S., Yoshida, R., Shigemura, N., Yanagawa, Y., Drucker, D. J., Margolskee, R. F., & Ninomiya, Y. (2015) · The FASEB Journal · doi:10.1096/fj.14-265355 · Cited by 106
Influence of temperature on taste perception
Talavera, K., Ninomiya, Y., Winkel, C., Voets, T., & Nilius, B. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6384-0 · Cited by 104
Metadata
- Authors
- Finger, T. E., Danilova, V., Barrows, J., Bartel, D. L., Vigers, A. J., Stone, L., Hellekant, G., & Kinnamon, S. C.
- Venue
- Science
- Published
- 2005-12-02
- Volume
- 310
- Issue
- 5753
- Pages
- 1495-1499
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115156649
- Cited by
- 818
- References
- 1
- FWCI
- 27.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Finger, T. E., Danilova, V., Barrows, J., Bartel, D. L., Vigers, A. J., Stone, L., Hellekant, G., & Kinnamon, S. C. (2005). ATP Signaling Is Crucial for Communication from Taste Buds to Gustatory Nerves. Science. https://doi.org/10.1126/science.1118435
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
