Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth
Abstract
Mutations in gld-1 cause lethal germline tumors in the nematode Caenorhabditis elegans . We find that a wide variety of mutations that extend C. elegans ' life span confer resistance to these tumors. The long life spans of daf-2/ insulin-receptor mutants were not shortened at all by gld-1 mutations; we attribute this finding to decreased cell division and increased DAF-16/p53–dependent apoptosis within the tumors. Mutations that increase life span by restricting food intake or inhibiting respiration did not affect apoptosis but reduced tumor cell division. Unexpectedly, none of these longevity mutations affected mitosis in normal germlines; this finding suggests that cellular changes that lead to longevity preferentially antagonize tumor cell growth.
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Recent work in Caenorhabditis elegans indicates that many lifespan-extending mutations converge on the activation of the worm form of p53.
“recent work in Caenorhabditis elegans indicates that many lifespanextending mutations converge on the activation of the worm form of p53 (ref. 33)”
From The common biology of cancer and ageing (2007) · cites this paper as [33]
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References 28 · Cited by 242
- Authors
- Pinkston, J. M., Garigan, D., Hansen, M., & Kenyon, C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kenyon, Cynthia
- Venue
- Science
- Published
- 2006-08-18
- Volume
- 313
- Issue
- 5789
- Pages
- 971-975
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037921221
- Cited by
- 242
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 13 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 10 · 2013: 12 · 2012: 16
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG000278)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- Caenorhabditis elegans, lifespan extension, germline tumors, GLD-1, apoptosis, tumor cell division, dietary restriction, respiration inhibition, aging and cancer
- MeSH terms
- Animals, Germ Cells, Insulin, Insulin-Like Growth Factor I, Longevity, Mitochondria, Mutation, Neoplasms, Oogenesis, Receptor, Insulin, Reproduction, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Apoptosis, Genes, Helminth, Models, Animal, Caenorhabditis elegans Proteins, Caloric Restriction, Cell Proliferation, Forkhead Transcription Factors
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