The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence for a Functional Second Thymus in Mice
Abstract
The thymus organ supports the development of T cells and is located in the thorax. Here, we report the existence of a second thymus in the mouse neck, which develops after birth and grows to the size of a small lymph node. The cervical thymus had a typical medulla-cortex structure, was found to support T cell development, and could correct T cell deficiency in athymic nude mice upon transplantation. The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production.
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Citations
Cites
Turnover of naive- and memory-phenotype T cells.
Tough, D. F., & Sprent, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1127 · Cited by 869
Cited by
Luche, H., Weber, O., Nageswara Rao, T., Blum, C., & Fehling, H. J. (2007) · European Journal of Immunology · doi:10.1002/eji.200636745 · Cited by 482
Self-citationMechanisms of thymus organogenesis and morphogenesis
Gordon, J., & Manley, N. R. (2011) · Development · doi:10.1242/dev.059998 · Cited by 293
Pathogenesis of prion diseases: current status and future outlook
Aguzzi, A., & Heikenwalder, M. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1492 · Cited by 207
Neonatal thymectomy reveals differentiation and plasticity within human naive T cells
van den Broek, T., Delemarre, E. M., Janssen, W. J. M., Nievelstein, R. A. J., Broen, J. C., Tesselaar, K., Borghans, J. A. M., Nieuwenhuis, E. E. S., Prakken, B. J., Mokry, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84997 · Cited by 104
Elevated levels of Wnt signaling disrupt thymus morphogenesis and function
Swann, J. B., Happe, C., & Boehm, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-00842-0 · Cited by 38
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Metadata
- Authors
- Terszowski, G., Müller, S. M., Bleul, C. C., Blum, C., Schirmbeck, R., Reimann, J., Pasquier, L. D., Amagai, T., Boehm, T., & Rodewald, H.-R.
- Venue
- Science
- Published
- 2006-04-14
- Volume
- 312
- Issue
- 5771
- Pages
- 284-287
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051437094
- Cited by
- 161
- References
- 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Terszowski, G., Müller, S. M., Bleul, C. C., Blum, C., Schirmbeck, R., Reimann, J., Pasquier, L. D., Amagai, T., Boehm, T., & Rodewald, H.-R. (2006). Evidence for a Functional Second Thymus in Mice. Science. https://doi.org/10.1126/science.1123497
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
