The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1
Abstract
Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An α-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended β hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.
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Cites
Spear, P. G., & Longnecker, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.19.10179-10185.2003 · Cited by 590
Cited by
Silver Nanoparticles as Potential Antiviral Agents
Galdiero, S., Falanga, A., Vitiello, M., Cantisani, M., Marra, V., & Galdiero, M. (2011) · Molecules · doi:10.3390/molecules16108894 · Cited by 963
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
White, J. M., Delos, S. E., Brecher, M., & Schornberg, K. (2008) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230802058320 · Cited by 892
Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P., & Ray, B. (2009) · Glycobiology · doi:10.1093/glycob/cwn092 · Cited by 391
Entry of herpesviruses into mammalian cells
Heldwein, E. E., & Krummenacher, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7570-z · Cited by 355
Self-citationHutt-Fletcher, L. M. (2007) · Journal of Virology · doi:10.1128/jvi.00445-07 · Cited by 323
Metadata
- Authors
- Heldwein, E. E., Lou, H., Bender, F. C., Cohen, G. H., Eisenberg, R. J., & Harrison, S. C.
- Venue
- Science
- Published
- 2006-07-14
- Volume
- 313
- Issue
- 5784
- Pages
- 217-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086769942
- Cited by
- 562
- References
- 1
- FWCI
- 27.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heldwein, E. E., Lou, H., Bender, F. C., Cohen, G. H., Eisenberg, R. J., & Harrison, S. C. (2006). Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1. Science. https://doi.org/10.1126/science.1126548
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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