The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis
Abstract
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK activation in cultured myotubes; in particular, the Dok-7 phosphotyrosine-binding domain and its target in MuSK are indispensable. Mice lacking Dok-7 formed neither acetylcholine receptor clusters nor neuromuscular synapses. Thus, Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK.
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Cites
An adaptive coding model of neural function in prefrontal cortex
Duncan, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35097575 · Cited by 874
MUSK, a new target for mutations causing congenital myasthenic syndrome
Chevessier, F., Faraut, B., Ravel-Chapuis, A., Richard, P., Gaudon, K., Bauché, S., Prioleau, C., Herbst, R., Goillot, E., Ioos, C., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh333 · Cited by 193
Cited by
Lrp4 is a receptor for Agrin and forms a complex with MuSK
Kim, N., Stiegler, A. L., Cameron, T. O., Hallock, P. T., Gomez, A. M., Huang, J. H., Hubbard, S. R., Dustin, M. L., & Burden, S. J. (2008) · Cell · doi:10.1016/j.cell.2008.10.002 · Cited by 676
IgG1 antibodies to acetylcholine receptors in ‘seronegative’ myasthenia gravis†
Leite, M. I., Jacob, S., Viegas, S., Cossins, J., Clover, L., Morgan, B. P., Beeson, D., Willcox, N., & Vincent, A. (2008) · Brain · doi:10.1093/brain/awn092 · Cited by 527
LRP4 serves as a coreceptor of Agrin
Zhang, B., Luo, S., Wang, Q., Suzuki, T., Xiong, W. C., & Mei, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.006 · Cited by 525
LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction
Weatherbee, S. D., Anderson, K. V., & Niswander, L. A. (2006) · Development · doi:10.1242/dev.02696 · Cited by 351
AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
Chen, H.-H., Yeo, H.-T., Huang, Y.-H., Tsai, L.-K., Lai, H.-J., Tsao, Y.-P., & Chen, S.-L. (2024) · Skeletal Muscle · doi:10.1186/s13395-024-00349-z · Cited by 14
Metadata
- Authors
- Okada, K., Inoue, A., Okada, M., Murata, Y., Kakuta, S., Jigami, T., Kubo, S., Shiraishi, H., Eguchi, K., Motomura, M., Akiyama, T., Iwakura, Y., Higuchi, O., & Yamanashi, Y.
- Venue
- Science
- Published
- 2006-06-23
- Volume
- 312
- Issue
- 5781
- Pages
- 1802-1805
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2128686747
- Cited by
- 439
- References
- 2
- FWCI
- 16.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Okada, K., Inoue, A., Okada, M., Murata, Y., Kakuta, S., Jigami, T., Kubo, S., Shiraishi, H., Eguchi, K., Motomura, M., Akiyama, T., Iwakura, Y., Higuchi, O., & Yamanashi, Y. (2006). The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis. Science. https://doi.org/10.1126/science.1127142
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